Sökning: "Neurofilament light"

Visar resultat 1 - 5 av 51 avhandlingar innehållade orden Neurofilament light.

  1. 1. Neurofilament light as a marker for neurodegenerative diseases

    Författare :Niklas Norgren; Torgny Stigbrand; Roland Carlsson; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; Neurofilament protein; ELISA; Cerebrospinal fluid; Neurodegenerative diseases; Immunologi; Immunology; Immunologi; immunologi; Immunology;

    Sammanfattning : Neurofilaments are the main cytoskeletal constituents in neuronal cells. They are belived to be important for maintaining the structural integrity and calibre of axons and dendrites thereby influencing the conduction velocity of nerve impulses. LÄS MER

  3. 2. Treatment with the monoclonal antibody rituximab in Multiple Sclerosis : a study based on an academic clinical trial

    Författare :Pierre de Flon; Anders Svenningsson; Martin Gunnarsson; Katarina Laurell; Sten Fredrikson; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Multiple sclerosis; Rituximab; Cytokines; Immunological profile; Neurofilament light; Treatment satisfaction; neurologi; Neurology;

    Sammanfattning : Background: Multiple sclerosis (MS) is a chronic, inflammatory disease, affecting the central nervous system. A growing number of disease modifying treatment alternatives entails a need for an individualised risk-benefit- convenience analysis in the counselling of patients and methods to monitor the treatment effect, including markers for subclinical inflammation. LÄS MER

  4. 3. Mapping the Huntington's disease process using cerebrospinal fluid analysis

    Författare :Valter Niemelä; Anne-Marie Landtblom; Dag Nyholm; Jimmy Sundblom; Edward Wild; Uppsala universitet; []
    Nyckelord :Neurodegeneration; Huntingtons disease; Neurogenetics; Neuroinflammation; Neurofilament light; tau; Proenkephalin; Neurology; Neurologi;

    Sammanfattning : Huntington's disease (HD) is an autosomal dominant neurodegenerative disorder, caused by a CAG-repeat expansion in the HTT-gene. Today there are no disease-modifying therapies (DMTs), but several promising clinical trials are underway, including therapies that reduce mutant huntingtin expression. LÄS MER

  5. 4. Markers and mechanisms of abnormal neurovascular development in the preterm infant

    Författare :William Hellström; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neonatology; Brain development; Extremely preterm infant; Brain volume; Retinopathy of prematurity; Insulin-like growth factor 1; Neurofilament light; Neurodevelopment;

    Sammanfattning : Background: The extremely preterm infant is at risk of lifelong neurodevelopmental impairments due to brain injuries or abnormal neurovascular development. Mechanisms are largely unknown and biomarkers for adverse outcomes are sparse. LÄS MER

  7. 5. Studies of cerebral blood flow and cerebrospinal fluid in childhood acute lymphoblastic leukemia

    Författare :Gustaf Österlundh; Göteborgs universitet; []
    Nyckelord :childhood acute lymphoblastic leukemia; methotrexate; neurotoxicity; cerebral blood flow; single photon emission computed tomography; cerebrospinal fluid; neuron-specific enolase; glia fibrillary acidic protein; neurofilament; ascorbyl radical;

    Sammanfattning : Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy and more than 80% of the patients are cured today. Treatment might cause side effects and central nervous system (CNS) irradiation has been replaced by systemic high-dose methotrexate (MTX) and intrathecal (IT) MTX due to the risk of late effects. LÄS MER