Sökning: "Immune inhibitory receptor"

Visar resultat 36 - 40 av 111 avhandlingar innehållade orden Immune inhibitory receptor.

  1. 36. Regulation of the pro-apoptotic protein Bim by T cell receptor triggering in human T cells

    Författare :Elena Sandalova; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Bim; Apoptosis; Mitochondria; CTLs; AICD; TCR activation;

    Sammanfattning : Bim is a significant pro-apoptotic member of Bcl-2 family of proteins; it is proved to be an important regulator of apoptosis: over the years it has been shown to play a pivotal role for the development and maintenance of homeostasis in many cellular systems and tissues. The Bcl-2 family of proteins is a group of key regulators of the mitochondrial, or intrinsic, pathway of apoptosis. LÄS MER

  3. 37. Immune deterioration in HIV-1 and HIV-2 infection with a focus on CD8 T cell exhaustion

    Författare :Lydia Scharf; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Thanks to the development of antiretroviral treatment (ART), human immunodeficiency virus (HIV) infection is now considered a chronic infection rather than the death sentence it used to be. Despite constant expansion and improvement of treatment options, even optimal therapy cannot prevent the impact of HIV on the human immune system. LÄS MER

  4. 38. Regulation of NK cell activity : studies of DAP12-associated receptors in immune synapse formation and in responses to cytomegalovirus infection

    Författare :Hanna Sjölin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :NK cells; DAP12; MCMV Cytokines; Receptors; Signaling; packages;

    Sammanfattning : Natural killer (NK) cell effector functions are important for innate resistance against tumor cells and viral infections. NK cells display a broad range of inhibitory and activating receptors on the cell surface, which ensure specificity. LÄS MER

  5. 39. Towards a detailed understanding of the red blood cell storage lesion : and its consequences for in vivo survival following transfusion

    Författare :Andreas Hult; Christer Malm; Per-Arne Oldenborg; Martin L. Olsson; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Red blood cell; erythrocyte; transfusion; macrophage; phagocytosis; storage lesion; eryptosis; Class A scavenger receptor; transfusion medicine; transfusionsmedicin;

    Sammanfattning : Red blood cells (RBCs) are vital for oxygen delivery to tissues and constitute the vast majority of all cells in blood. After leaving the red bone marrow as mature cells, RBCs have a lifespan of approximately 120 days before they are removed from the circulation by macrophages, mainly in the spleen and liver. LÄS MER

  7. 40. Interaction between the nervous and immune systems in allergic contact dermatitis : a clinical and experimental study with emphasis on the role of VIP and serotonin

    Författare :Lena Bondesson Lundeberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :patch test; nickel sulphate; serotonin antagonists; VIP receptors; immunohistochemistry; ELISA; RIA; HPLC;

    Sammanfattning : The interaction between the nervous and immune systems was investigated in allergic contact dermatitis (ACD) with emphasis on the role of vasoactive intestinal peptide (VIP) and serotonin (S-HT). Dual dose-dependent effects of VIP on the migration of mononuclear and polymorphonuclear leukocytes were found. LÄS MER