Sökning: "Immune inhibitory receptor"
Visar resultat 21 - 25 av 111 avhandlingar innehållade orden Immune inhibitory receptor.
21. Checkpoint inhibitor-induced adverse events in the CNS - T-cell characteristics and biomarkers
Sammanfattning : Immune checkpoint inhibitors (ICI) activate T cells to kill cancer cells by blocking inhibitory receptors PD-1 (nivolumab; nivo) or CTLA-4 (ipilimumab; ipi). Activated T cells can also attack any healthy organ, causing unpredictable immune related adverse events (irAE). The risk of irAE is highest when treating with ipi and nivo simultaneously. LÄS MER
22. Immune recognition molecules in synaptic plasticity and regeneration of spinal motoneurons
Sammanfattning : This thesis is based on the emerging concept that pattern recognition molecules, originally characterized in the immune system, may be expressed and used by neurons to mediate non-immune functions. In line with this concept, the major histocompatibility complex (MHC) class I and certain complements proteins have been implicated in synaptic plasticity in the developing visual system. LÄS MER
23. Neuroblastoma as a target for effector mechanisms of the immune system
Sammanfattning : Neuroblastoma (NB) is the most common solid extracranial tumor in children. Despite intensive multimodal treatment, the prognosis for high-risk NB patients remains poor and therefore new treatment modalities are needed. The main aim of my studies was to assess NB as a target for cytotoxic T lymphocyte (CTL)-mediated immunotherapy. LÄS MER
24. Formation of the inhibitory KIR repertoire in human natural killer cells
Sammanfattning : Natural killer (NK) cells are lymphocytes of the innate immune system that are able to secrete cytokines and detect virus infected and transformed cells. Contrary to T cells, NK cells recognize targets that lack expression of MHC class I molecules at the cell surface, a phenomenon referred to as “missing self” recognition. LÄS MER
25. Early induced immune responses : regulation of dendritic cell and NK cell functions
Sammanfattning : The evolution of the advanced vertebrate adaptive immune system has required co-evolution of sophisticated immune regulating systems that determine immune class of cytokines, antibodies as well as effector mechanisms used by killer cells. The co-ordination of these responses are likely to be carried out by dendritic cells (DC) under the influence of the tissue cells and innate immune cells resident in the tissue from where the DC originates. LÄS MER