Sökning: "Igf2"

Visar resultat 16 - 20 av 39 avhandlingar innehållade ordet Igf2.

  1. 16. Epigenetic mechanisms and regulatory aspects of human cancer and neural progenitor cells : implications for diagnosis and therapy

    Författare :Monira Akhtar; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Epigenetic is defined as heritable modification or properties of the functional genome that are not directly embedded in the DNA sequence. Epigenetic changes include DNA methylation, histone modifications and RNA-mediated gene silencing. LÄS MER

  3. 17. Epigenetic Regulation of Higher Order Chromatin Conformations and Gene Transcription

    Författare :Anita Göndör; Reinald Fundele; Thomas Graf; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; Genomic imprinting; Chromatin; Epigenetics; Cancer; Developmental biology; Utvecklingsbiologi;

    Sammanfattning : Epigenetic states constitute heritable features of the chromatin to regulate when, where and how genes are expressed in the developing conceptus. A special case of epigenetic regulation, genomic imprinting, is defined as parent of origin-dependent monoallelic expression. LÄS MER

  4. 18. Genetic and epigenetic studies of diabetes and diabetic nephropathy with focus on the IGF-IGFBP axis

    Författare :Tianwei Gu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Diabetes and diabetic nephropathy (DN) are complex diseases reflecting a complex interplay between genetic and non-genetic factors. The insulin-like growth factor (IGF) - IGF binding protein (IGFBP) axis plays an important role in the development of diabetes and DN. LÄS MER

  5. 19. Chromatin Insulators and CTCF: Architects of Epigenetic States during Development

    Författare :Rituparna Mukhopadhyay; Rolf Ohlsson; Karim Malik; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; DNA methylation; CTCF; Chromatin insulators; Microarray; Utvecklingsbiologi; Developmental biology; Utvecklingsbiologi;

    Sammanfattning : A controlled and efficient coordination of gene expression is the key for normal development of an organism. In mammals, a subset of autosomal genes is expressed monoallelically depending on the sex of the transmitting parent, a phenomenon known as genomic imprinting. LÄS MER

  7. 20. The Epigenetics of Gene Transcription and Higher Order Chromatin Conformation

    Författare :Vijay Kumar Tiwari; Rolf Ohlsson; Terumi Kohwi-Shigematsu; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; DNA-protein interactions; Nuclear organization; Transcriptional regulation; Higher order chromatin conformations; Epigenetic reprogramming; Utvecklingsbiologi; Developmental biology; Utvecklingsbiologi;

    Sammanfattning : It is becoming increasingly clear that long-range control of gene expression is mediated through direct physical interactions between genes and regulatory elements, either intra- or interchromosomally. In addition to transcriptional initiation, formation of active chromatin hubs seem to be crucial for increased transcriptional efficiency as well as insulation from neighbouring heterochromatic environment. LÄS MER