Sökning: "Heterocyclic Compounds"

Visar resultat 1 - 5 av 45 avhandlingar innehållade orden Heterocyclic Compounds.

  1. 1. Silaborations of Unsaturated Compounds

    Författare :Martin Gerdin; Christina Moberg; Kálmán Szabó; KTH; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; allylboration; bismetallation; boron; carbocyclization; catalysis; 1; 3-diene; enantioselective; 1; 6-enyne; interelement; N-heterocyclic carbene; nickel; palladium; phosphine; phosphoramidite; platinum; reaction mechanism; silaboration; silicon; silylborane; stereoselective; Chemistry; Kemi;

    Sammanfattning : This thesis deals with the development of transition metal-catalyzed silaborations of 1,3-dienes and 1,6-enynes. The first part of the thesis describes the development of the enantioselective 1,4-silaboration of 1,3-cyclohexadiene. A number of chiral metal-ligand complexes were evaluated. LÄS MER

  3. 2. Construction of Five-Membered Heterocyclic Compounds via Radical Cyclization

    Författare :Stefan Berlin; Lars Engman; Mario D. Bachi; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; radical; cyclization; carbonylation; melatonin; pyrrolidine; pyrrolidin-3-one; tetrahydrofuran-3-one; Organisk kemi; Organic chemistry; Organisk kemi; organisk kemi; Organic Chemistry;

    Sammanfattning : This thesis describes how radical cyclization chemistry can be applied for the construction of heterocyclic compounds.In the first part, a series of electron deficient α-phenylselenenylalkenes were prepared via a PhSeCl-addition/HCl-elimination sequence. LÄS MER

  4. 3. The GABAA Receptor as Target for Novel Heterocyclic Compounds

    Författare :Jakob Nilsson; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Ligands for the benzodiazepine-binding site of the GABAA receptor can belong to structurally diverse classes of compounds including, in spite of the name of the binding site, many non-benzodiazepine structures. The GABAA receptor is a ligand-gated ion channel assembled of five subunits from eight different classes with multiple isoforms. LÄS MER

  5. 4. Transition metal-catalyzed reduction of carbonyl compounds : Fe, Ru and Rh complexes as powerful hydride mediators

    Författare :Elina Buitrago; Hans Adolfsson; Robert Morris; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Asymmetric catalysis; amino acid; N-heterocyclic carbene; iron; ruthenium; rhodium; mechanistic investigation; kinetic study; asymmetric transfer hydrogenation; hydrosilylation; organisk kemi; Organic Chemistry;

    Sammanfattning : A detailed mechanistic investigation of the previously reported ruthenium pseudo-dipeptide-catalyzed asymmetric transfer hydrogenation (ATH) of aromatic ketones was performed. It was found that the addition of alkali metals has a large influence on both the reaction rate and the selectivity, and that the rate of the reaction was substantially increased when THF was used as a co-solvent. LÄS MER

  7. 5. Aromatic Allylation via Diazotization; Application in synthesis of heterocyclic compounds

    Författare :Fredrik Ek; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Bengamide analogue.; parallel synthesis; trimethylsilyl azide; cycloaddition; imidazole; fused tetrazole derivatives; iodocyclization; benzazepine; tert-butyl nitrite; allylic bromide; aromatic allylation; diazotization; Organic chemistry; Organisk kemi;

    Sammanfattning : A new method for allylation of aromatic systems has been developed. A number of arylamines were converted via diazotization to the corresponding allylaromatic compounds using tert-butyl nitrite and an excess of allylic bromides with complete regioselectivity. Electron-withdrawing groups, in the aromatic moiety, were necessary to obtain good yields. LÄS MER