Sökning: "HNF4A"

Visar resultat 1 - 5 av 6 avhandlingar innehållade ordet HNF4A.

  1. 1. Cellular and molecular mechanisms of kidney injury and regeneration

    Författare :Michelle Kha; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; kidney; injury; regeneration; repair; scattered tubular cells; proximal tubular cells; podocytes; SOX9; HNF4A;

    Sammanfattning : The prevalence of kidney disease is constantly increasing with about 600 million people afflicted globally. Kidney disease may result in end stage renal disease, a condition that requires renal replacement therapy in the form of kidney transplantation or dialysis. LÄS MER

  3. 2. Genome-Wide Studies of Transcriptional Regulation in Mammalian Cells

    Författare :Ola Wallerman; Claes Wadelius; Jussi Taipale; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ChIP; ChIP-chip; ChIP-seq; transcription factors; motif discovery; nucleosome positioning; HepG2; genome-wide; RNA-seq; Medical genetics; Medicinsk genetik; Medical Genetics; Medicinsk genetik;

    Sammanfattning : The key to the complexity of higher organisms lies not in the number of protein coding genes they carry, but rather in the intrinsic complexity of the gene regulatory networks. The major effectors of transcriptional regulation are proteins called transcription factors, and in this thesis four papers describing genome-wide studies of seven such factors are presented, together with studies on components of the chromatin and transcriptome. LÄS MER

  4. 3. Studies on the molecular regulation of bile acids and lipoproteins in human liver

    Författare :Lisa-Mari Nilsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Elevated lipid levels in the bloodstream, in particular high levels of LDL cholesterol, are a major risk factor for the development of atherosclerosis. The liver has a central role in cholesterol metabolism and is the only organ capable of a quantitative elimination of cholesterol from the body. LÄS MER

  5. 4. The involvement of INSIGs, DGAT1 and APOB in human lipid metabolism

    Författare :Sergey Krapivner; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Atherosclerosis is a complex pathophysiological condition characterized by lipid accumulation in the vascular wall. These lipids are derived from the lipoproteins present in the circulation. LÄS MER

  7. 5. Genetic and immunological risk factors of gestational diabetes mellitus

    Författare :Nael Shaat; diabetes och endokrinologi Genomik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; GDM; Association; genetics; gestational diabetes mellitus metabolic syndrome; MODY; type 1 diabetes; risk factors; type 2 diabetes; Endocrinology; diabetology; secreting systems; autoimmunity; Endokrinologi; sekretion; diabetologi;

    Sammanfattning : Gestational diabetes mellitus (GDM) is a heterogeneous disorder that is defined as carbohydrate intolerance with onset or first recognition during pregnancy. Impaired beta-cell function and insulin resistance are the hallmarks of GDM. LÄS MER