Sökning: "Glucosamine"

Visar resultat 1 - 5 av 27 avhandlingar innehållade ordet Glucosamine.

1. 1. Articular cartilage proteoglycan biosynthesis and sulfation

   Författare :Chengjuan Qu; Mikko Lammi; Heikki Helminen; Juha Töyräs; Anna-Marja Säämänen; Finland Kuopio University of Kuopio Anatomy Department of Biomedicine; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Cartilage; Chondrocytes metabolism; Chondroitin sulfates; Glycosaminoglycans; Osteoarthritis; Proteoglycans; Glucosamine; Sulfation; Biochemistry; biokemi; cellforskning; cell research; Orthopaedics; ortopedi;

   Sammanfattning : Glucosamine (GlcN) and glucosamine sulfate (GS) have been used to treat the patients with osteoarthritis(OA) as a disease-modifying agent. Previousin vitro studies have focused on the effects of GlcN or GSon cartilage metabolism, whereas in vivo studies have investigated their potential for the treatment of OA. LÄS MER

3. 2. N-Unsubstituted Glucosamine Residues in Heparan Sulfate and Their Potential Relation to Alzheimer's Disease

   Författare :Camilla Westling; Ulf Lindahl; Svein Olav Kolset; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; heparan sulfate; N-unsubstituted glucosamine; Alzheimer s disease; amyloid beta peptide; amyloidosis; 10E4 antibody; fibroblast growth factor 2; Biokemi; Biochemistry; Biokemi;

   Sammanfattning : Heparan sulfate (HS) is a linear polysaccharide, located on the surface and in the extracellular matrix of most cells, that regulates functions of numerous proteins. HS-protein interaction is mainly mediated by sulfate groups found in N-sulfated (NS) regions of the HS, but may also involve rare HS substituents such as N-unsubstituted glucosamine (GlcNH2) residues. LÄS MER

4. 3. Medication in temporomandibular disorders and bruxism

   Författare :Birgitta Johansson Cahlin; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; temporomandibular disorders; sleep bruxism; glucosamine sulfate; pramipexole; dopamine agonist; botulinum toxin; cerebral palsy;

   Sammanfattning : The aim of this thesis was to explore aspects of pharmaceutical intervention in temporomandibular disorders (TMDs) and bruxism. Sleep bruxism is a movement disorder that signals disturbed sleep and constitutes a significant health problem due to TMDs, headache and tooth wear. LÄS MER

5. 4. Production of neocartilage tissues using primary chondrocytes

   Författare :Janne Ylärinne; Mikko Lammi; Chengjuan Qu; Mats Brittberg; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; primary chondrocytes; articular cartilage; tissue engineering; neocartilage; scaffold; scaffold-free; hyaluronan; self-assembling peptide; TGF-β3; glucosamine sulfate; hypoxia; hypertonic medium; glucose;

   Sammanfattning : Hyaline cartilage is a highly specialized tissue, which plays an important role in the articulating joints of an individual. It provides the joints with a nearly frictionless, impact resisting surface to protect the ends of the articulating bones. LÄS MER

7. 5. Synthesis of inositol phosphoglycans and analogues thereof

   Författare :Katinka Ruda; JS Brimacombe; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; Organisk kemi; Organic Chemistry; organisk kemi;

   Sammanfattning : This thesis describes the synthesis of inositol phosphoglycans (IPG) corresponding to glycosyl-phosphatidylinositol (GPI) anchors found on the cell surface of the parasite Leishmania. Synthesis of an IPG which is a putative second messenger for insulin, and of analogues thereof is also discussed. LÄS MER