Sökning: "GCH1"

Hittade 3 avhandlingar innehållade ordet GCH1.

  1. 1. Genetics and Labor Pain Behavior

    Författare :Fatimah Dabo Pettersson; Helena Åkerud; Inger Sundström Poromaa; Fred Nyberg; Pelle Lindqvist; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; anxiety; beta-endorphin; depressed mood; GCH1; labor analgesia; labor pain; OPRM1; SNP; Obstetrik och gynekologi; Obstetrics and Gynaecology;

    Sammanfattning : Labor may perhaps be the most painful a woman might experience, although characterized by large inter-individual variability. The perceived pain during labor is the result of diverse factors, i.e. her previous pain experiences, the analgesia she receives and maybe also her genes. LÄS MER

  3. 2. Provoked vestibulodynia : studies on pain genetics and pain co-morbidity

    Författare :Ulrika Heddini; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :provoked vestibulodynia;

    Sammanfattning : Objective: The purpose of this thesis was to investigate a possible genetic predisposition for developing provoked vestibulodynia (PVD), focusing on previously defined single nucleotide polymorphisms (SNPs) in three genes with a known influence on endogenous pain modulation: GCH1, OPRM1 and 5HT-2A. We also investigated the effects of any potential interactions between these SNPs and the use of hormonal contraceptives, serum levels of β-endorphin and symptoms of anxiety and depression, on the risk of developing PVD and general pain sensitivity. LÄS MER

  4. 3. Novel strategies for enzyme replacement with gene therapy in models of Parkinson’s disease

    Författare :Erik Cederfjäll; Brain Repair and Imaging in Neural Systems (BRAINS); []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; AAV vectors; dopamine; enzyme replacement; gene regulation; GTP cyclohydrolase 1; L-DOPA; tyrosine hydroxylase; Parkinson’s disease;

    Sammanfattning : Parkinson’s disease is a brain disorder characterized by loss of dopaminergic neurons in the midbrain, resulting in the characteristic motor symptoms: resting tremor, rigidity, akinesia and postural instability. Symptomatic treatment is based on reconstituting the loss of dopamine in the brain, primarily by oral administration of its precursor L-DOPA. LÄS MER