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Visar resultat 6 - 10 av 898 avhandlingar som matchar ovanstående sökkriterier.

  1. 6. Regulation of Elovl and fatty acid metabolism

    Författare :Annelie Brolinson; Anders Jacobsson; Jaap Keijer; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; fatty acid metabolism; fatty acid elongation; Physiology; Fysiologi; Physiology; fysiologi;

    Sammanfattning : Fatty acids are important regulators in the control of mammalian energy homeostasis. They are ingested in the diet but a significant amount are also endogenously produced by de novo lipogenesis. LÄS MER

  3. 7. Expression of Manganese Lipoxygenase and Site-Directed Mutagenesis of Catalytically Important Amino Acids : Studies on Fatty Acid Dioxygenases

    Författare :Mirela Cristea; Ernst H. Oliw; Chao Su; Olof Rådmark; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical pharmacology; Dioxygenase; Gaeumannomyces graminis; lipoxygenase; Magnaporthe grisea; oxylipin; Pichia pastoris; hydroperoxide isomerase; polyunsaturated fatty acids; Farmaceutisk farmakologi; Pharmaceutical pharmacology; Farmaceutisk farmakologi;

    Sammanfattning : Polyunsaturated fatty acids can be bioactivated by two families of dioxygenases, which either contain non-heme iron (lipoxygenases) or heme (cyclooxygenases, linoleate diol synthases and α-dioxygenases).Lipoxygenases and their products play important roles in the pathophysiology of plants and fungi. LÄS MER

  4. 8. Role of Fatty Acid Composition in Non-Alcoholic Fatty Liver Disease: a Dietary Perspective : Results from Interventional and Observational Studies

    Författare :Michael Fridén; Ulf Risérus; Fredrik Rosqvist; Helen Lindqvist; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Fatty acids; Diet; Biomarkers; NAFLD; Liver fat; Fibrosis; Cirrhosis; HCC; Nutrition; Nutrition;

    Sammanfattning : The overall aim of this doctoral thesis was to investigate the role of circulating, liver and dietary fatty acids in non-alcoholic fatty liver disease (NAFLD). For circulating and liver fatty acids, special emphasis was given to fatty acids reflecting diet. LÄS MER

  5. 9. Synthetic biology approaches for improving production of fatty acid-derived compounds in cyanobacteria

    Författare :Ivana Cengic; Elton P. Hudson; Mathias Uhlén; Annegret Wilde; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; cyanobacteria; metabolic engineering; surface display; CRISPRi; fatty alcohols; fatty acid synthesis; aldehyde deformylating oxygenase; Bioteknologi; Biotechnology;

    Sammanfattning : The environmental consequences associated with the use of fossil-sourced fuels and chemicals have brought with it a realization that future development must move in a more sustainable direction. Currently available biofuels or renewably produced chemical, such as bioethanol or biodiesel, are produced from microbial fermentation of sugar-rich crops or by chemical conversion of natural oils or fats. LÄS MER

  7. 10. Predictors of Dementia : Insulin, Fatty Acids and Vascular Risk Factors

    Författare :Elina Rönnemaa; Lena Kilander; Lars Lannfelt; Björn Zethelius; Laura Fratiglioni; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; dementia; Alzheimer’s disease; vascular dementia; insulin secretion; diabetes; fatty acids; epidemiology; vascular risk factors; Geriatrics; Geriatrik;

    Sammanfattning : Identification of modifiable risk factors for Alzheimer’s disease (AD) is crucial in order to diminish suffering from this devastating disease. The aim of this thesis was to investigate if different aspects of glucose metabolism, insulin, fatty-acid composition or other vascular risk factors predict the future development of AD and dementia. LÄS MER