Sökning: "Dosing strategy"

Visar resultat 11 - 15 av 18 avhandlingar innehållade orden Dosing strategy.

1. 11. Engineering alternative scaffold proteins for conditional targeting

   Författare :Malin Jönsson; Sophia Hober; Mark Howarth; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Protein Engineering; Conditional targeting; Calcium; Biotechnology; Bioteknologi;

   Sammanfattning : Engineering naturally occurring proteins enables us to customize affinity domains according to our specific needs, tailoring them to become an important tool in a wide array of applications limited merely by our creativity. One of nature’s ways to regulate protein activity is by creating a functional change through alteration of a protein’s tertiary structure upon interaction with metal ions. LÄS MER

3. 12. 3D printing of lipid-based formulations into personalized solid oral dosage forms

   Författare :Jenny Johannesson; Christel Bergström; Alexandra Teleki; Mattias Paulsson; Maria Strömme; Abdul Basit; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; poorly water-soluble drug; lipid-based formulation; Pickering emulsion; emulsion gel; semi-solid extrusion; 3D printing; lipid tablet; personalized dosage form; Farmaceutisk vetenskap; Pharmaceutical Science;

   Sammanfattning : The pharmaceutical development process starts with patient populations and their unmet therapeutic needs. Traditional pharmaceutical manufacturing of solid oral dosage forms is based on the strategy of one-size-fits-all. This is problematic, especially for patient populations with high patient-to-patient variability, as in pediatrics. LÄS MER

4. 13. Methodological studies on non-linear mixed effects model building

   Författare :E. Niclas Jonsson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacy; FARMACI; PHARMACY; FARMACI; Biopharmaceutics; biofarmaci;

   Sammanfattning : Population analysis of pharmacokinetic/pharmacodynamic (PK/PD) data by the use of non-linear mixed effects modeling offers a number of benefits over traditional methods of analyzing this type of data. These benefits include the possibility to appropriately characterize the typical PK/PD behaviour in the population as well as the associated variability when only a few observations are available for each individual. LÄS MER

5. 14. Optimization of cyclophosphamide therapy based on pharmacogenetics

   Författare :Parvaneh Afsharian; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Cyclophosphamide; Pharmacogenetics; Pharmacokinetics; Cytochrome P450; CYP2136; Ciprofloxacin;

   Sammanfattning : Cyclophosphamide (CPA) is one of the most broadly used anticancer agents. CPA is also a potent immunosuppressive agent that is used for the treatment of autoimmune diseases. CPA is a prodrug that is activated in liver by a 4-hydroxylation reaction catalyzed by cytochrome P450 (CYP) enzymes. LÄS MER

7. 15. Immune cells in chronic lymphocytic leukemia and Hodgkin lymphoma in relation to tumor burden and treatment

   Författare :Tom Adriaan Mulder; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : B-cell malignancies are a heterogeneous group of cancers that originate from lymphoidlineage cells that are responsible for humoral immunity. When B-cell development goes wrong, chronic lymphocytic leukemia (CLL) and classical Hodgkin lymphoma (cHL), among other malignancies, may arise. Recent advances in the treatment of these diseases, e.g. LÄS MER