Sökning: "Dose planning"

Visar resultat 21 - 25 av 120 avhandlingar innehållade orden Dose planning.

  1. 21. Aspects of dose, dose rate and radioisotopes in brachytherapy of uveal melanoma

    Författare :Maria Fili; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Uveal melanomas constitute melanomas arising from the choroid, the ciliary body or the iris, and in adults stands for the most common primary malignant intraocular tumor. It has a high risk of metastatic spread followed by inevitable death, and unfortunately the prognosis has not improved over the last decades. LÄS MER

  3. 22. On Quality in Radiotherapy Treatment Plan Optimisation

    Författare :Hunor Benedek; Lund Medicinsk strålningsfysik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Pareto optimisation; Pareto fronts; Dose prediction; Machine learning; Deliverable treatment plans; Volumetric modulated arc therapy; IMRT; patient-specific plan quality; plan quality; Multi Criteria Optimisation; Automated Treatment Planning;

    Sammanfattning : Radiotherapy is one of the essential treatments used in the fight against cancer. The goal of radiotherapy is to deliver a high dose of ionising radiation to the tumour volume and at the same time minimise the effect on healthy tissue by reducing the radiation to critical organs. LÄS MER

  4. 23. Model-Based Optimization of Clinical Trial Designs

    Författare :Camille Vong; Mats O. Karlsson; Andrew C. Hooker; Lena E. Friberg; Marylore Chenel; Oliver Sander; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nonlinear mixed-effects models; pharmacometrics; likelihood ratio test; NONMEM; power; sample size; study design; proof-of-concept; dose-finding; population optimal design; LOQ; BQL data; neutropenia; docetaxel; myelosuppression; thrombocytopenia; MTD; Bayesian methods; 3 3 algorithm; dose escalation study; Pharmaceutical Science; Farmaceutisk vetenskap;

    Sammanfattning : General attrition rates in drug development pipeline have been recognized as a necessity to shift gears towards new methodologies that allow earlier and correct decisions, and the optimal use of all information accrued throughout the process. The quantitative science of pharmacometrics using pharmacokinetic-pharmacodynamic models was identified as one of the strategies core to this renaissance. LÄS MER

  5. 24. 177Lu-DOTA-octreotate Radionuclide Therapy of Neuroendocrine Tumours : Dosimetry-Based Therapy Planning and Outcome

    Författare :Ulrike Garske-Román; Barbro Eriksson; Anders Sundin; Jens Sörensen; Dik Kwekkeboom; Uppsala universitet; []
    Nyckelord :;

    Sammanfattning : Peptide receptor radionuclide therapy for the internal radiation of neuroendocrine tumours expressing somatostatin receptors has made great advances and offers promising results. 177Lu-DOTA-octreotate is one of the most widely used radiopeptides, but kidneys and bone marrow are organs at risk. LÄS MER

  7. 25. Microdosimetric description of beam quality and biological effectiveness in radiation therapy

    Författare :Aris Tilikidis; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Dose-response relationship; radiation; Radiotherapy: adverse effects; Radiotherapy dosage; Radiotherapy planning; computer-assisted; Strålningsfysik; Medicin Radioterapi;

    Sammanfattning : .... LÄS MER