Sökning: "DNA methylation analysis"
Visar resultat 6 - 10 av 112 avhandlingar innehållade orden DNA methylation analysis.
6. DNA methylation as a prognostic marker in clear cell Renal Cell Carcinoma
Sammanfattning : Clear cell renal cell carcinoma (ccRCC) is the most common type of renal cell carcinoma worldwide. Metastatic ccRCC is correlated to poor prognosis whereas non-metastatic disease has a 5-year survival rate up to 90%. LÄS MER
7. Machine Learning Based Analysis of DNA Methylation Patterns in Pediatric Acute Leukemia
Sammanfattning : Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer in the Nordic countries. Recent evidence indicate that DNA methylation (DNAm) play a central role in the development and progression of the disease. LÄS MER
8. DNA methylation in T cell leukaemia
Sammanfattning : T cell acute lymphoblastic leukaemia (T-ALL) is a predominantly paediatric cancer that stems from malignant transformation of developing T cells. While the disease has an overall survival rate of 80%, the intense chemotherapy treatment causes severe toxicity and long-term side effects. LÄS MER
9. The Epigenome of Multiple Myeloma : From genome-wide analysis to pharmacological manipulation
Sammanfattning : Nowadays epigenetic dysregulation is known to play a crucial role in virtually all cancers. In multiple myeloma (MM), an extensively heterogeneous malignancy, the key common feature among patients is the gene silencing imposed by the PRC2 complex through the addition of H3K27me3. LÄS MER
10. lmproving diagnosis of central nervous system tumours using genetic and epigenetic tools
Sammanfattning : Brain tumor diagnostics has traditionally been based on histopathology stains. The introduction of immunohistochemistry stains resulted in improved ability to classify these often devastating tumors. The understanding of molecular markers in central nervous system tumors has improved substantially in recent decades. LÄS MER