Sökning: "DNA methylation-based classification"
Hittade 3 avhandlingar innehållade orden DNA methylation-based classification.
1. lmproving diagnosis of central nervous system tumours using genetic and epigenetic tools
Sammanfattning : Brain tumor diagnostics has traditionally been based on histopathology stains. The introduction of immunohistochemistry stains resulted in improved ability to classify these often devastating tumors. The understanding of molecular markers in central nervous system tumors has improved substantially in recent decades. LÄS MER
2. Resolving the Genomic Complexity of Pediatric Acute Lymphoblastic Leukemia
Sammanfattning : Acute lymphoblastic leukemia (ALL) is the most common pediatric cancer in the Nordic countries. Structural chromosomal rearrangements are a hallmark of ALL and represent key markers for diagnosis, risk stratification and prognosis. LÄS MER
3. Deregulated epigenetics and cancer stem cells in brain tumours
Sammanfattning : Glioblastoma (GBM) is an incurable brain tumour with dismal prognosis as the median survival for afflicted patients is only 8 months. Aberrations of epigenetic processes, which govern gene expression, are involved in cancer, but these epigenetic mechanisms are reversible and can potentially be corrected by treatment. LÄS MER