Sökning: "DNA lesion"

Visar resultat 31 - 35 av 42 avhandlingar innehållade orden DNA lesion.

  1. 31. Roles of NUDT5 and NUDT15 beyond oxidized nucleotide sanitation and their potential as therapeutic targets

    Författare :Nicholas Carl Kristoffer Valerie; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The nucleotide precursor pool is readily susceptible to numerous sources of modification and damage, including alkylation, deamination and oxidation/nitrosylation, among others; most of which have deleterious effects on nucleic acid integrity and cellular fitness. In addition to DNA repair mechanisms, these metabolic byproducts are kept in check by so-called sanitation or “housekeeping” enzymes, chief among them the NUDIX hydrolase superfamily. LÄS MER

  3. 32. Vaccine effectiveness against HPV infections

    Författare :Hanna Kann; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Infections with human papilloma viruses (HPV) are the most prevalent sexually transmitted diseases. The vast majority of the sexually active population acquires them during lifetime but almost all HPV infections become resolved within a year. LÄS MER

  4. 33. Population structure and pathogenicity evolution of Phytophthora infestans affects epidemiology and management of late blight disease

    Författare :Anne Njoroge; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Sound management of late blight, the disease caused by the notorious oomycete pathogen Phytophthora infestans (Mont.) de Bary, is dependent on the pathogen’s population biology. However, for P. LÄS MER

  5. 34. Renal cell carcinoma : factors of importance for follow-up and survival

    Författare :Farhood Iranparvar Alamdari; Börje Ljungberg; Torgny Rasmuson; Sven Lundstam; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; renal cell carcinoma; follow-up; VEGFR-1; PS; ESR; stage; prognosis; metastasis; surveillance; TNM classification; adrenalectomy; angiogenesis; VEGF; Urology and andrology; Urologi och andrologi;

    Sammanfattning : Background: Renal cell carcinoma (RCC) is most lethal of the urological cancers, with more than 40% dying of the disease. About 30% of the patients have metastases at initial diagnosis and up to 40% undergoing nephrectomy for localized RCC develop metastasis. LÄS MER

  7. 35. Immunogenetics and treatment of experimental autoimmune encephalomyelitis

    Författare :Robert Weissert; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Multiple sclerosis; experimental autoimmune encephalomyelitis; major histocompatibility complex; myelin; myelin oligodendrocyte glycoprotein; T cell receptor;

    Sammanfattning : Experimental autoimmune encephalomyelities (EAE) is a model of multiple sclerosis (MS). This experimental central nervous system (CNS) disease can be induced in rats by immunization with components of the CNS myelin sheath. LÄS MER