Sökning: "Cell Cycle genetics"
Visar resultat 1 - 5 av 49 avhandlingar innehållade orden Cell Cycle genetics.
1. PARN - A Tale of A de-Tailor : Functional importance of poly(A) degradation in developmental and telomere biology disorders
Sammanfattning : Poly(A)-specific ribonuclease (PARN) is a eukaryotic 3’-5’exoribonuclease that removes poly(A) tails of many coding and non-coding RNAs. In this thesis, we have studied the physiological role of PARN. LÄS MER
2. Genetic mechanisms regulating proliferation and cell specification in the Drosophila embryonic CNS
Sammanfattning : The central nervous system (CNS) consists of an enormous number of cells, and large cellular variance, integrated into an elaborate network. The CNS is the most complex animal organ, and therefore its establishment must be controlled by many different genetic programs. LÄS MER
3. Purification of general RNA polymerase II transcription factors from mouse for studies of proliferation-specific transcription
Sammanfattning : Accurate initiation of transcription by RNA polymerase II depends on general transcription factors (GTFs), which include the TATA-binding protein (TBP) and the transcription factors (TF) IIB, IIF, IIE and IIH. In order to reconstitute mouse transcription in vitro, we cloned the genes encoding mouse TFIIB, and both subunits of TFIIE and TFIIF from a mouse cDNA library. LÄS MER
4. The Role of Stat1 in Retinoic Acid-induced Myelomonocytic Differentiation of Human Leukemia Cells
Sammanfattning : All-trans retinoic acid (ATRA), a biologically active metabolite of vitamin A, is a powerful inducer of terminal differentiation and growth arrest of several myeloid cell lines in vitro. Although the efficacy of ATRA as an anti-cancer drug has been demonstrated by the successful treatment of acute promyelocytic leukemia (APL), knowledge concerning the molecular mechanisms directing ATRA-induced differentiation and cell cycle arrest of myeloid cells is lacking. LÄS MER
5. Developmental phase transitions in Norway spruce : a molecular approach to identify regulatory mechanisms
Sammanfattning : Plant development proceeds through distinct phases that are controlled by complex networks of regulatory genetic circuits and fine-tuned by environmental and endogenous cues. Many of these regulatory networks have been unraveled in annual and perennial angiosperms, while they remain predominantly unknown in ecologically and economically important gymnosperm species such as the conifers. LÄS MER
