Sökning: "CD3ζ"
Hittade 4 avhandlingar innehållade ordet CD3ζ.
1. Functional studies of candidate genes contributing to type 1 diabetes in the NOD mouse
Sammanfattning : Type 1 Diabetes (T1D) is an autoimmune disorder caused by both genetic and environmental factors. The non-obese diabetic (NOD) mouse is one of the best and most commonly studied animal models for T1D. This mouse strain spontaneously develops diabetes through a process that closely resembles the human pathogenesis. LÄS MER
2. Studies on neuronal signaling in the hippocampus related to development, pathogenesis and treatment of mood disorders
Sammanfattning : The hippocampus is a central organ in the brain which is interconnected with different cortical regions and plays an important role in memory and learning processes. The anatomical position of the hippocampus together with the special sensitivity of its neurons renders it vulnerable to brain injury. LÄS MER
3. Defining the potential of mesothelin-directed CAR T cells for the treatment of ovarian cancer
Sammanfattning : Chimeric antigen receptor (CAR) T cells have revolutionized the field of immunotherapy, by redirecting T cell specificity and effector functions. Co-stimulation has proven to be crucial for therapeutic effectiveness of CAR T cells and remarkable clinical response rates have been achieved with second generation CD19-directed CAR T cells containing either a CD28 or 4-1BB co-stimulatory domain for the treatment of B cell malignancies. LÄS MER
4. Cellular and personalized therapies in multiple myeloma with special emphasis on retargeted natural killer cells
Sammanfattning : Multiple myeloma (MM) is a clonal plasma cell malignancy accounting for approximately 10% of all hematological cancer cases. Despite considerable advances in MM management, which led to exceptional response and survival rates, patients still experience relapse and cure remains elusive. LÄS MER