Sökning: "Bronchoconstriction"

Visar resultat 11 - 15 av 27 avhandlingar innehållade ordet Bronchoconstriction.

  1. 11. Regulation of spontaneous tone in guinea pig trachea

    Författare :Staffan Skogvall; Neurofysiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; tetrodotoxin; lidocaine; substance P; tachykinin; prostaglandin; indomethacin; capsaicin; neuroepithelial endocrine cells; epithelium; oxygen; oscillations; spontaneous tone; Asthma; airway smooth muscle; electrical field stimulation.; Physiology; Fysiologi;

    Sammanfattning : Asthma is a common disease, characterized by periods of bronchoconstriction of unclear origin. This thesis examines a specific behavior of airway smooth muscle, the so-called spontaneous airway tone. It was suspected that a defect regulation of this tone may be a cause of asthmatic bronchoconstriction. LÄS MER

  3. 12. Bronchoprovocation studies to define mechanisms in asthma and airway inflammation

    Författare :Nikolaos Lazarinis; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Bronchial provocations with a variety of stimuli have been widely used over the past 70 years in both asthma research as well as in daily clinical praxis in order to aid the physician to establish the asthma diagnosis. In research, the bronchoprovocation model represents an excellent tool to better understand asthma pathophysiology, and to assess the effects of different interventions and new investigational therapies. LÄS MER

  4. 13. Acute lung failure induced by tricyclic antidepressants : an experimental evaluation

    Författare :Karin Svens; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :ARDS; tricyclic antidepressants; isolated lungs; rat; endothelin; endothelial cells; tight junctions;

    Sammanfattning : The tricyclic antidepressant drugs (TCA) have, over the years, been reported to be able to cause adult respiratory distress syndrome (ARDS)/acute lung injury in connection with overdose, and are currently among the most common cause of self-poisoning. Approximately 10% of all TCA overdose patients develop ARDS, and the treatment of these patients, irrespective of the event causing ARDS, is mainly supportive. LÄS MER

  5. 14. The role of inflammatory cells in sarcoidosis and asthma

    Författare :Mu Nie; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Immuno-homeostasis refers to maintaining a delicate balance between immune responses and tolerance. It relies on the harmonious interplay of various inflammatory cells, including macrophages, monocytes, dendritic cells, T cells, mast cells, etc. LÄS MER

  7. 15. Nitric oxide and eicosanoids : significance and interactions during antigen-induced responses in peripheral lung tissue

    Författare :Anna-Karin Larsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Nitric oxide; leukotrienes; prostaglandins; histamine; ovalbumin; contractions; distal lung; rat; human; guinea pig; precision-cut lung slices; mast cell;

    Sammanfattning : Asthma means difficulty in breathing and is described as a chronic, inflammatory disorder that produces narrowing of the lower respiratory tract. The allergen-induced asthmatic bronchoconstriction is primarily caused by an IgE-mediated release of the mast cell mediators, histamine and eicosanoids (leukotrienes and prostanoids). LÄS MER