Sökning: "Brain tumors"

Visar resultat 36 - 40 av 168 avhandlingar innehållade orden Brain tumors.

1. 36. Functional investigation of prognostic biomarkers and therapeutic targets in glioma brain tumors

   Författare :Kaveh M Goudarzi; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Gliomas are known to be the most prevalent primary tumors of the central nervous system, of which glioblastoma is the most aggressive type with a median survival less than 2 years and no available cure. Studies in this thesis investigated the significance of two potentially important proteins in glioma biology, the transcription factor PROX1 and the histone chaperone NPM1, and the interplay of the therapeutic targets p53 and mTOR. LÄS MER

3. 37. Synergistic effects of mesenchymal stromal cells and immunotherapy in experimental brain tumors

   Författare :Salina Gunnarsson; Neurokirurgi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mesenchymal stromal cells; rat; IFNγ; IL-7; immunotherapy; glioma;

   Sammanfattning : Glioblastoma multiforme (GBM) is the most common and aggressive form of primary brain tumor. In spite of surgical resection, combined radiation therapy and chemotherapy, the mean survival is less than 15 months following diagnosis. LÄS MER

4. 38. Breast cancer : brain metastases and treatment aspects

   Författare :Gabriella Frisk; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Background: In Sweden breast cancer is the most common malignant cancer disease among women, with 8000 new individual cases each year. The prognosis is generally very good, but nevertheless many patients still die of breast cancer every year. LÄS MER

5. 39. Guidance and Visualization for Brain Tumor Surgery

   Författare :Filipe Miguel Maria Marreiros; Örjan Smedby; Sandro Rossitti; Karin Wårdel; Anders Ynnerman; Ole Jacob Elle; Linköpings universitet; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES;

   Sammanfattning : Image guidance and visualization play an important role in modern surgery to help surgeons perform their surgical procedures. Here, the focus is on neurosurgery applications, in particular brain tumor surgery where a craniotomy (opening of the skull) is performed to access directly the brain region to be treated. LÄS MER

7. 40. MRI at 3 T of brain functions and fibre tracts adjacent to intracranial tumors

   Författare :Danielle van Westen; Lund Diagnostisk radiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; medical instrumentation; Klinisk fysiologi; radiologi; tomografi; medicinsk instrumentering; radiology; tomography; Clinical physics; Medicin människa och djur ; Medicine human and vertebrates ; somatosensory cortex; diffusion magnetic resonance imaging; neoplasms; Functional Magnetic Resonance Imaging;

   Sammanfattning : The aims of the studies were: to evaluate the spatial resolution of fMRI at 3 T by studying fingersomatotopy in area 3 b of the primary sensory area (Paper 1); to investigate the potential of fMRI at 3T as a clinical tool for preoperative evaluation of patients with intracranial tumors (Paper 2); to investigate the effect of glioma resection on the spatial extent of fMRI activation as compared to the normal within-subject variability (Paper 3); to determine whether the apparent diffusion coefficient (ADC) and fractional anisotropy (FA) can distinguish tumor-infiltrated edema of gliomas from pure edema of meningiomas and metastases (Paper 4). Results: Strict somatotopic organisation in the primary sensory cortex was shown in the group average; at the subject level the thumb was located laterally, anteriorly and inferiorly to the little finger in 94 % of subjects (Paper 1). LÄS MER