Sökning: "Biologi med inriktning mot strukturbiologi"

Visar resultat 16 - 20 av 23 avhandlingar innehållade orden Biologi med inriktning mot strukturbiologi.

  1. 16. From Structure to Function with Binding Free Energy Calculations for Codon Reading, Riboswitches and Lectins

    Författare :Johan Sund; Åqvist Johan; Javier Luque; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; binding free energy; ribosome; codon reading; release factor; mitochondrial translation; purine riboswitch; lectin; molecular dynamics; free energy perturbation; Biology with specialization in Structural Biology; Biologi med inriktning mot strukturbiologi;

    Sammanfattning : Molecular association is part of many important processes in living cells. Computational methods for calculating binding free energies allows for a quantitative examination of biomolecular structures and hypotheses drawn from biochemical experiments. LÄS MER

  2. 17. Structural studies of small viruses using an X-ray Free Electron Laser

    Författare :Anna Munke; Marvin Seibert; Dirk Hasse; Inger Andersson; Carl Caleman; Maria Selmer; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Physics with specialization in Biophysics; Fysik med inriktning mot biofysik;

    Sammanfattning : X-ray crystallography has since its introduction been the most successful technique for solving protein structures. Viruses however, often possess structural components such as fibrils, tails and envelopes that make them difficult or impossible to crystallize. LÄS MER

  3. 18. Molecular Metamorphosis in Transcriptional Regulation

    Författare :Malin Lüking; Johan Elf; Victor Muñoz; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Protein-DNA interactions; Facilitated diffusion; Binding Kinetics; Molecular Simulations; Fluorescence Microscopy; Biology with specialization in Structural Biology; Biologi med inriktning mot strukturbiologi; Biology with specialization in Molecular Biotechnology; Biologi med inriktning mot molekylär bioteknik;

    Sammanfattning : The foundation of all life is the interaction of molecules. Molecular interaction occurs in the tightly packed cytoplasm. In this crowded environment, the molecules need to be able to establish stable interactions with specific interaction partners, and with specific ones only. LÄS MER

  4. 19. Calculations of Reaction Mechanisms and Entropic Effects in Enzyme Catalysis

    Författare :Masoud Kazemi; Johan Åqvist; Per E. M. Siegbahn; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Enzyme catalysis; Entropy; Cytidine deamination; Ribosome; Peptidyl-tRNA hydrolysis; Peptide bond formation; Empirical valence bond method; Density functional theory; Biology with specialization in Structural Biology; Biologi med inriktning mot strukturbiologi; Biokemi; Biochemistry; Biology with specialization in Molecular Biotechnology; Biologi med inriktning mot molekylär bioteknik;

    Sammanfattning : Ground state destabilization is a hypothesis to explain enzyme catalysis. The most popular interpretation of it is the entropic effect, which states that enzymes accelerate biochemical reactions by bringing the reactants to a favorable position and orientation and the entropy cost of this is compensated by enthalpy of binding. LÄS MER

  5. 20. Structural studies on the extracellular flavocytochrome cellobiose dehydrogenase from Phanerochaete chrysosporium

    Författare :Martin Hällberg; Andrea Mattevi; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; cellobiose dehydrogenase; flavocytochrome; hydride transfer; radical mechanism; X-ray crystallography; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi; Biology; with specialization in structural biology; biologi; med inriktning mot strukturbiologi;

    Sammanfattning : Microorganisms that degrade lignocellulose play an important role in maintaining the global carbon cycle. Under cellulolytic conditions, the fungus Phanerochaete chrysosporium produces an extracellular flavocytochrome, cellobiose dehydrogenase (CDH), with a proposed role in lignocellulose degradation. LÄS MER