Sökning: "Peptide bond formation"
Visar resultat 1 - 5 av 33 avhandlingar innehållade orden Peptide bond formation.
1. Characterising Halogen Bonding in a Cooperative Model System
Sammanfattning : Non-covalent interactions are the main driving factor for secondary structure formation of biomacromolecules and are of enormous importance for the direction of molecular recognition events, for example those of importance for drug discovery. Profound understanding of these interactions is of vital importance to achieve high affinity and selectivity of a ligand to a chosen target. LÄS MER
2. Calculations of Reaction Mechanisms and Entropic Effects in Enzyme Catalysis
Sammanfattning : Ground state destabilization is a hypothesis to explain enzyme catalysis. The most popular interpretation of it is the entropic effect, which states that enzymes accelerate biochemical reactions by bringing the reactants to a favorable position and orientation and the entropy cost of this is compensated by enthalpy of binding. LÄS MER
3. New Proteomics Methods and Fundamental Aspects of Peptide Fragmentation
Sammanfattning : The combination of collision-activated dissociation, (CAD) and electron capture dissociation, (ECD) yielded a 125% increase in protein identification. The S-score was developed for measuring the information content in MS/MS spectra. This measure made it possible to single out good quality spectra that were not identified by a search engine. LÄS MER
4. An Investigation of Peroxidase Activity in Biomimetic and Biological Systems
Sammanfattning : In order to create a heme environment which permits biomimicry of heme-containing plant peroxidases and investigate the role played by the vinyl side chains of the porphyrin ring on the stability and, possibly, catalytic activity of model compounds, a number of new synthetic microperoxidases -– hemin-6(7)-gly-his methyl ester (HGH) and hemin-6(7)-gly-gly-his methyl ester (HGGH) and hemin-6,7-bis(gly-gly-his methyl ester) (H2GGH) as well as mesohemin-6(7)-gly-gly-his methyl ester (MGGH) and deuterohemin-6(7)-gly-gly-his methyl ester (DGGH) have been prepared by condensation of a peptide residue with the propionic side chains of hemin, mesohemin and deuterohemin, respectively. Reactivity studies towards different organic and inorganic substrates showed that not only five- but also six-coordinate hemin peptide complexes catalyze the oxidation of substrates by H2O2. LÄS MER
5. Molecular mechanisms and complete antigen formation in allergic contact dermatitis
Sammanfattning : Allergic contact dermatitis (ACD) is a common T cell mediated skin disease. Small reactive organic molecules called haptens induce ACD. Haptens are not recognized by themselves, but need to bond to endogenous proteins in the skin, and processed further into complete antigens. Antigen specific T cells then recognize the resulting antigen. LÄS MER