Sökning: "Avdelningen För Translationell Cancerforskning"

Visar resultat 26 - 30 av 30 avhandlingar innehållade orden Avdelningen För Translationell Cancerforskning.

  1. 26. Cancer and Therapy: A look into stemness and the tumour microenvironment

    Författare :Carmen Rodriguez; Avdelningen för translationell cancerforskning; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; COMP; STRIPAK; Notch; p21; oncofetal chondroitin sulfate; therapy; tumour microenvironment;

    Sammanfattning : Therapy is the often-used treatment for cancer patients, even those that undergo resection surgery. While milestones have been surpassed throughout the decades for a number of cancer types, there are those that comprise of characteristics limiting effectiveness of treatments. LÄS MER

  3. 27. The impact of Bcl-3 expression and signaling in cancer

    Författare :Karunakar Saamarthy; Avdelningen för translationell cancerforskning; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cyclin D1; BCL3ANT; Colorectal cancer; Melanoma; Prostate cancer; ID; IL-6; Bcl-3;

    Sammanfattning : Bcl-3 is a proto-oncogene and belongs to the inhibitor of κB (IκB) family and is known to be upregulated in numerous cancers. Bcl-3 can initiate transcription of different genes involved in cell survival and cell growth. LÄS MER

  4. 28. Mechanisms of therapy resistance in acute lymphoblastic leukemia

    Författare :Kinjal Shah; Avdelningen för translationell cancerforskning; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ALL; B-ALL; T-ALL; dexamethasone; FLT3; Signaling pathways; BCL2; resistance; PLK1; synergy;

    Sammanfattning : Acute lymphoblastic leukemia (ALL) is a highly aggressive pediatric cancer that can affect both B cells and T cells. The advent of new therapies has increased the cure rates for both B-ALL and T-ALL patients. However, some patients still experience relapse with a variable response to the treatment and display poor survival. LÄS MER

  5. 29. Deregulation and editing of microRNAs in metastatic prostate cancer

    Författare :Gjendine Voss; Avdelningen för translationell cancerforskning; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; prostate cancer; bone metastasis; microRNA; RNA editing; A-to-I editing; ADAR; miR-96; miR-379;

    Sammanfattning : Prostate cancer bone metastasis is still not fully understood, and increased knowledge could aid in the development of better treatment options for patients in the future. This thesis focuses on microRNAs (miRNAs), which modulate gene expression in healthy and tumour cells. LÄS MER

  7. 30. Tumor Suppressor function of the deubiquitinating enzyme BAP1 and its substrate gamma-tubulin In regulation of cell cycle and genome stability

    Författare :Reihaneh Zarrizi; Avdelningen för translationell cancerforskning; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : In normal cells, the cell cycle is controlled by a complex series of signalling pathways by which a cell grows, replicates its DNA and divides. The critical task of the cell cycle is to ensure that DNA is faithfully replicated and that identical chromosomal copies are distributed equally to two daughter cells during mitosis with the help of the mitotic spindle. LÄS MER