Sökning: "Signaling pathways"

Visar resultat 1 - 5 av 652 avhandlingar innehållade orden Signaling pathways.

  1. 1. Signaling pathways in Drosophila immunity

    Författare :Shiva Seyedoleslami Esfahani; Ylva Engström; Steven Wasserman; Stockholms universitet; []
    Nyckelord :Drosophila immunity; signaling pathways; Cactus; NFκB; molekylärbiologi; Molecular Biology;

    Sammanfattning : Drosophila relies on innate immunity to protect itself from its hostile environment throughout its life cycle. Despite the remarkable progress in understanding many aspects of Drosophila immunity, there are still big gaps in our knowledge. LÄS MER

  2. 2. On boundary value problems for intracellular subdiffusion and signaling pathways, and for geometric flows

    Författare :Tobias Gebäck; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; boundary value problems; diffusion-reaction equations; signaling pathways; anomalous diffusion; pseudo-differential equations; fluorescence correlation spectroscopy; immersed interface method; Boolean grids; mean curvature flow; boundary value problams; flourescence correlation spectroscopy; pseudo-differential equations;

    Sammanfattning : The main part of this thesis concerns mathematical models for diffusion of proteins inside cells, including reactions between the proteins. Initially, such models are applied to describe signaling pathways in yeast cells, and the properties of the model are studied, especially in relation to models that do not include diffusion. LÄS MER

  3. 3. HIF-dependent Signaling Pathways in Cancer

    Författare :Elinn Johansson; Avdelningen för translationell cancerforskning; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer; Hypoxia; ccRCC; glioma; CD44; Notch1; reactive astrocytes;

    Sammanfattning : The cellular response to hypoxia, primarily orchestrated by hypoxia-inducible factors (HIFs; mainly HIF-1α and HIF-2α), is at the center of several signaling pathways conferring aggressive tumor behavior. HIFs may be crucially involved in tumor initiation, as seen in clear cell renal cell carcinoma, as well as maintenance of resistance cancer stem cell phenotypes, as observed in glioma. LÄS MER

  4. 4. Studies on ITK-SYK signaling pathways

    Författare :Alamdar Hussain; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Sammanfattning : Chromosomal alterations are frequent causes of cancer. Until now, SYK is reported in two different chromosomal translocation events generating the ITK-SYK-fusion protein in a subset of peripheral T cell lymphomas and the TEL-SYK fusion protein in a case of myelodysplastic syndrome. LÄS MER

  5. 5. Studies on the transmembrane signaling of β1 integrins

    Författare :Annika Armulik; Uppsala universitet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Integrin β1; signaling; transmembrane domain; CAS; focal adhesion kinase; Biokemi; Biochemistry; Biokemi; Medical Biochemistry; medicinsk biokemi;

    Sammanfattning : Integrins are heterodimeric cell surface receptors, composed of an α and a β subunit, mainly binding for extracellular matrix proteins. lntegrin subunit β1 can combine with at least 12 a subunits and thus form the biggest subfamily within the integrin family. LÄS MER