Sökning: "Anticancer drugs"

Visar resultat 21 - 25 av 86 avhandlingar innehållade orden Anticancer drugs.

1. 21. Cytochrome P450 pharmacogenetics : implications for anticancer and warfarin therapy

   Författare :Mi-Young Lee; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : There is a pronounced interindividual variability in the drug disposition, response and toxicity. Pharmacogenetics aims at identifying genetic biomarkers that could help to increase the drug efficacy, reduce adverse drug reactions and contribute to the development of personalized medicine. LÄS MER

3. 22. Nucleic Acids as Drug Targets -Interactions of Platinum Complexes, Polyamines, and siRNA with DNA and RNA Models

   Författare :Margareta Hägerlöf; Biokemi och Strukturbiologi; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Kinetics; Kemi; Chemistry; AU-rich region; siRNA; Circular Dichroism; Polyamine; Modified Nucleoside; HPLC; Thermodynamic Stability; cisplatin; Hairpin; DNA and RNA conformation; RNA; DNA; Anticancer Drug; Platinum Complexes;

   Sammanfattning : Drugs targeting nucleic acids were studied in DNA and RNA model systems. The effects were investigated with respect to structural and thermodynamic influence, kinetics, and biological function. The drugs employed in this thesis were anticancer active platinum(II) complexes, polyamine derivatives, and siRNA. LÄS MER

4. 23. Pharmacometrics to improve evaluation and individualization of anticancer drug treatment

   Författare :Sreenath Madathil Krishnan; Lena Friberg; Mats Karlsson; Zinnia Parra Gillén; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nonlinear mixed effect models; NONMEM; pharmacodynamics; survival modeling;

   Sammanfattning : The success rate in clinical development of newer anti-cancer molecules is the lowest compared to other major diseases. Improving the success rate and better early evaluation of efficacy of anti-cancer drugs remain challenging obstacles. LÄS MER

5. 24. Metabolic regulation and anticancer drug resistance in the yeast Saccharomyces cerevisiae

   Författare :Mattias Carlsson; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Sammanfattning : Cancer is a malignant neoplastic tissue. The pyrimidine analogue 5-fluorouracil is an anticancer drug used against several types of cancer. It owes its specificity against neoplasms due to the higher rate of nutrient uptake, RNA and DNA synthesis, and in particular the higher rate of nucleobase scavenging and salvage of neoplastic cells. LÄS MER

7. 25. Development and application of a patient-derived xenograft platform to test anticancer agents

   Författare :Berglind Einarsdottir; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; malignant melanoma; patient-derived xenografts; MTH1; pre-clinical trial; Karonudib;

   Sammanfattning : Malignant melanoma is the most aggressive form of skin cancer and incidence rates are on the rise. Despite recent improvements in treatment options, the disease still remains lethal. Which calls for expedited solutions. LÄS MER