Sökning: "Anticancer drugs"

Visar resultat 11 - 15 av 86 avhandlingar innehållade orden Anticancer drugs.

  1. 11. Copper-transporting proteins and their interactions with platinum-based anticancer substances

    Författare :Maria Espling; Pernilla Wittung-Stafshede; Oleg Dmitriev; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cisplatin; Atox1; copper transport; anticancer drug; resistance; platinum; spectroscopy.; biologisk kemi; biological chemistry;

    Sammanfattning :   Cisplatin (CisPt) is an important drug that is used against various cancers, including testicular, ovarian, lung, head, and neck cancer. However, its effects are limited by cellular resistance. LÄS MER

  3. 12. Development and application of new methods for anticancer drug discovery and early evaluation

    Författare :Sumeer Dhar; Uppsala universitet; []
    Nyckelord :Medical sciences; Drug development; tumor cell lines; cytotoxic drugs; neural network; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; klinisk farmakologi; Clinical Pharmacology;

    Sammanfattning : A non-clonogenic assay using the redox dye Alamar Blue and primary human tumor cells (PHTC) from patients and human tumor cell lines (HTCL) was established for rapid screening and evaluation of anticancer drugs. PHTC cultures from chronic lymphocytic leukemia (CLL) and ovarian carcinoma (Ovca) were compared with renal carcinoma (ACHN) and lymphocytic (CCRF-CEM) HTLCs in response to 63 toxic or non-toxic compounds. LÄS MER

  4. 13. Mitochondria : a target for anticancer therapy

    Författare :Björn Kruspig; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Mitochondria possess a central role in several cellular metabolic pathways, maintenance of calcium homeostasis, production of reactive oxygen species (ROS) and in the regulation of various cell death modalities. A majority of cancers demonstrate aberrations in mitochondrial functions, which were shown to contribute to tumourigenesis. LÄS MER

  5. 14. Mathematical model development to investigate the pharmacokinetic variability of two anticancer drugs

    Författare :Martin Fransson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Pharmacokinetic variability in a population is the variability in plasma drug concentrations among individuals. It may, for instance, be caused by differences in genes coding for drug-transport proteins and metabolizing enzymes, amount of body fat, age, sex, patient compliance, diet or disease progression. LÄS MER

  7. 15. Plurifaceted proteomics in studying cellular dynamics and action mechanisms of anticancer drugs

    Författare :Pierre Sabatier; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Mass spectrometry (MS)-based proteomics has developed tremendously in recent years and was the leading technology for many novel methods to study protein chemistry. Contrary to classical approaches based on Western blot, MS-based approaches are mostly unbiased. LÄS MER