Sökning: "Amino acid sequence"

Visar resultat 21 - 25 av 346 avhandlingar innehållade orden Amino acid sequence.

  1. 21. Molecular mechanisms and biological consequences of the production of non-canonical D-amino acids in bacteria

    Författare :Alena Aliashkevich; Felipe Cava; Fredrik Almqvist; Andrew J Roe; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Bacteria; cell wall; peptidoglycan; D-amino acids; LD-transpeptidase;

    Sammanfattning : Most bacteria possess a vital net-like macromolecule – peptidoglycan (PG). PG encases bacteria around the cytoplasmic membrane to withstand the high internal turgor pressure and thereby protect the cell from bursting. In addition, PG is a major morphological determinant of bacteria being both required and sufficient to maintain cell shape. LÄS MER

  3. 22. From protein sequence to structural instability and disease

    Författare :Lixiao Wang; Uwe Sauer; Sven Hovmöller; Umeå universitet; []
    Nyckelord :protein domain; remote homologue; intrinsically disorder unstructured proteins; protein function; point mutation; protein family protein stability; HMMs; CRFs; SVMs;

    Sammanfattning : A great challenge in bioinformatics is to accurately predict protein structure and function from its amino acid sequence, including annotation of protein domains, identification of protein disordered regions and detecting protein stability changes resulting from amino acid mutations. The combination of bioinformatics, genomics and proteomics becomes essential for the investigation of biological, cellular and molecular aspects of disease, and therefore can greatly contribute to the understanding of protein structures and facilitating drug discovery. LÄS MER

  4. 23. Enzymes in different pathways of bile acid biosynthesis

    Författare :Catrin Furster; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; Biochemistry; biokemi;

    Sammanfattning : Enzymes catalyzing side chain hydroxylations and dehydrogenation/isomerization in different pathways of bile acid biosynthesis were studied.Pig liver mitochondrial sterol 27-hydroxylase (CYP27A) was found to catalyze 24- and 25-hydroxylation of cholesterol in addition to the known 27-hydroxylation. LÄS MER

  5. 24. Amino acid predictors of HIV-1 coreceptor use in different subtypes and their application to antiretroviral treatment

    Författare :Lotta Pramanik Sollerkvist; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The human immunodeficiency virus type 1 (HIV-1) group M is responsible for the HIV pandemic and has great genetic variability. The main subtypes and circulating recombinant forms belonging to this group differ in their worldwide distribution, their disease progression patterns, as well as in their coreceptor use phenotype distributions. LÄS MER

  7. 25. Regulation of tartrate-resistant purple acid phosphatase by proteolytic processing in rat

    Författare :Jenny Ljusberg-Sjölander; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Purple acid phosphatase; enzyme catalysis; proteolytic processing;

    Sammanfattning : Purple acid phosphatase (PAP) is an iron-containing binuclear acid metallohydrolase with a characteristic purple colour, also referred to as tartrate-resistant acid phosphatase (TRAP), uteroferrin or type 5 acid phosphatase. PAP is highly expressed in osteoclasts and has a role in bone resorption. LÄS MER