Sökning: "Alzheimer’s sciences"

Visar resultat 6 - 10 av 351 avhandlingar innehållade orden Alzheimer’s sciences.

1. 6. Detection of Lipids and Proteins on Biological Surfaces using Imaging Mass Spectrometry

   Författare :Louise M Carlred; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; ToF-SIMS; GM1; cholesterol; Amyloid-β; phospholipids; Imaging Mass Spectrometry; Alzheimer’s disease; sulfatides; QCM-D; MALDI;

   Sammanfattning : Time-of-flight secondary ion mass spectrometry (ToF-SIMS) is a technique that can be used for imaging the spatial distribution of many different molecules at the same time. It is very sensitive for detection of small biomolecules, such as lipids, whereas larger biomolecules, such as peptides and proteins, cannot be detected as intact entities due to fragmentation. LÄS MER

3. 7. Inequity in mind. On the Social and Genetic Risk Factors of Dementia and Their Interactions

   Författare :Caroline Hasselgren; Göteborgs universitet; []
   Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Dementia; APOE ε4; health inequity; longitudinal population studies; class; sex gender; fundamental cause theory;

   Sammanfattning : The present thesis seeks to further explain the occurrence of Alzheimer’s disease and other dementias by studying the long-term impact of class- and gender-based inequities as well as the extent to which they potentially moderate genetic risk. Central to this endeavour is the recognition of social inequity as multifaceted, and of potential intersections between different drivers of structural (dis)advantage in relation to individual health prospects. LÄS MER

4. 8. Regulation of apoptotic processes in neurodegeneration and cancer : In vitro studies on human neuroblastoma cells

   Författare :Tom Gatsinzi; Kerstin Iverfeldt; Thomas J. Sayers; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

   Sammanfattning : Apoptosis is a highly controlled process of cell death, which is vital for maintenance of all multicellular organisms. Aberrant regulation of apoptosis can give rise to pathological conditions such as neurodegenerative diseases and cancer. LÄS MER

5. 9. Translational research of the quaking gene : Focusing on the conjunction between development and disease

   Författare :Bryn Farnsworth; Lina Emilsson; Roman Chrast; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; QKI; glia; oligodendrocyte; Alzheimer s; schizophrenia; zebrafish; statistics; morpholino; Biologi med inriktning mot evolutionär organismbiologi; Biology with specialization in Evolutionary Organismal Biology;

   Sammanfattning : Quaking (QKI) is an RNA binding protein involved in the post-transcriptional regulation of gene expression. Originally identified as the cause of hypomyelination in a mouse mutant, it has since been consistently implicated in a wide range of neurological diseases. LÄS MER

7. 10. Imaging of lipids and proteins in Alzheimer's disease using Time-of-Flight Secondary Ion Mass Spectrometry

   Författare :Louise M Carlred; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; QCM-D; fluorescence microscopy; ToF-SIMS; Amyloid-β; immunohistochemistry; Sulfatides; antibodies; liposomes; Alzheimer’s disease; Cholesterol;

   Sammanfattning : Alzheimer’s disease (AD) is a neurodegenerative disease characterized by the formation of senile plaques. These plaques, which consist of aggregations of a peptide called amyloid-β, are deposited in-between the nerve cells in the brain, where they disrupt the signaling processes. LÄS MER