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Visar resultat 1 - 5 av 6 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Secondary Nucleation in Amyloid Formation

    Författare :Mattias Törnquist; NanoLund: Centre for Nanoscience; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Alzheimer s disease; amyloid; Ab42; aggregation mechanism; aggregation kinetics; secondary nucleation; Protein misfolding;

    Sammanfattning : Research into Alzheimer's disease is still hampered by a lack of fundamental understanding of the underlying mechanisms. While the aggregation of the amyloid β peptide (Aβ) into amyloid fibrils is highly implicated as a key factor in the disease, the molecular nature of its involvement has proven complex and elusive. LÄS MER

  3. 2. Big Lessons from Small Bacteria : Following Photo-driven Processes in Photosynthetic Systems with Multidimensional Spectroscopy

    Författare :Egle Bukarte; Kemisk fysik; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Two-dimensional electronic spectroscopy; Ultrafast spectroscopy; Chlorophyll; Bacterial reaction centers; Photosynthetic unit; Purple bacteria; Green bacteria;

    Sammanfattning : Sunlight is a plentiful, continuously flowing source of energy, fuelling life on Earth as we know it. To use this potential, plants, cyanobacteria and photosynthetic bacteria evolved to absorb solar radiance and convert it into a chemically stable form by performing a process known as photosynthesis. LÄS MER

  4. 3. Biomarkers in preclinical familial Alzheimer disease

    Författare :Steinunn Thordardottir; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Background: Alzheimer disease (AD) is a neurodegenerative disorder, characterized by the accumulation of b-amyloid (Ab) plaques and tangles consisting of hyperphosphorylated tauprotein in the brain. It accounts for 60-70% of dementia cases, making it the most common cause of dementia. LÄS MER

  5. 4. Neuroinflammation and its resolution in Alzheimer's disease

    Författare :Ying Wang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Alzheimer's disease (AD) is the most common dementia with high prevalence among an increasing aged population. Despite the existence of symptom-reliving drugs for AD, the clinical trials performed until now have failed to find drugs that cure or stop the progression of AD. New perspectives and strategies for treatments are therefore direly needed. LÄS MER

  7. 5. Unravelling protein stability and aggregation

    Författare :Tanja Weiffert; NanoLund: Centre for Nanoscience; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; protein stability; protein aggregation; amyloid beta peptide; protein stabilization; split GFP; monellin; secretagogin; ; aggregation kinetics; toxicity; aggregation mechanism; coaggregation;

    Sammanfattning : Proteins are complex macromolecules that are fundamental to all living species. The stability of proteins are governed by non-covalent forces within the protein and between the protein and its surrounding environment. LÄS MER