Sökning: "aggregation mechanism"

Visar resultat 1 - 5 av 105 avhandlingar innehållade orden aggregation mechanism.

  1. 1. SOD1 Aggregation Relevance of thermodynamic stability

    Detta är en avhandling från Department of Biochemistry and Biophysics, Stockholm University

    Författare :Lisa Lang; Stockholms universitet.; [2017]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Aggregation; misfolding; Superoxide dismutase SOD1 ; Amyotrophic lateral sclerosis ALS ; unfolding; thermodynamic stability; biokemi; Biochemistry;

    Sammanfattning : Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease affecting the upper and lower motor neurons causing muscle atrophy and paralysis followed by death. Aggregates containing superoxide dismutase (SOD1) are found as pathological hallmark in diseased ALS patients. LÄS MER

  2. 2. Unravelling protein stability and aggregation

    Detta är en avhandling från Media-Tryck, Lund University, Sweden

    Författare :Tanja Weiffert; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; Lund University.; Lunds universitet.; [2018-10]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; protein stability; protein aggregation; amyloid beta peptide; protein stabilization; split GFP; monellin; secretagogin; ; aggregation kinetics; toxicity; aggregation mechanism; coaggregation;

    Sammanfattning : Proteins are complex macromolecules that are fundamental to all living species. The stability of proteins are governed by non-covalent forces within the protein and between the protein and its surrounding environment. LÄS MER

  3. 3. On the molecular mechanisms of the amyloid β-peptide aggregation

    Detta är en avhandling från Lund University, Faculty of Science, Department of Chemistry

    Författare :Kalyani Sanagavarapu; Lund University.; Lunds universitet.; [2019-01]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; protein aggregation; amyloid β-peptide; aggregation kinetics; aggregation mechanism N-terminus; mutations; variants; sequence determinants; ; cross-seeding;

    Sammanfattning : The pathogenesis of Alzheimer’s disease is widely believed to be due to production and deposition of the amyloid β-peptide. Several variants of the Aβ peptide are known to exist in in vivo. Variations include mutations or additional functional groups attached to residue side chains and may affect the aggregation process. LÄS MER

  4. 4. Isotopes as Mechanism Spies Nucleophilic Bimolecular Substitution and Monoamine Oxidase B Catalysed Amine Oxidation Probed with Heavy Atom Kinetic Isotope Effects

    Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

    Författare :Susanna MacMillar; Uppsala universitet.; [2006]
    Nyckelord :Organic chemistry; nucleophilic bimolecular substitution SN2; kinetic isotope effects; precision conductometry; monoamine oxidase B MAO B; reaction mechanism; carbon 11C 14C kinetic isotope effect; ion pairing triple-ion formation; para-substituted benzyl chlorides; tetrabytylammonium cyanide; Organisk kemi;

    Sammanfattning : This thesis concerns the study of reaction mechanisms by means of kinetic isotope effects (KIEs). Studies of the nucleophilic bimolecular substitution (SN2) reaction had the dual purpose of improving our fundamental understanding of molecular reactivity and assessing the ability of kinetic isotope effects to serve as mechanistic tools. LÄS MER

  5. 5. Amyloid beta aggregation kinetics : The role of intrinsic and extrinsic factors

    Detta är en avhandling från Lund University, Faculty of Science, Department of Biochemistry and Structural Biology

    Författare :Xiaoting Yang; Lund University.; Lunds universitet.; [2016]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Alzheimer s disease; Abeta; aggregation; kinetics; secondary nucleation;

    Sammanfattning : Cerebral senile plaque is one of the main pathologies of Alzheimer's disease (AD). The amyloid cascade hypothesis suggests that the aggregation of amyloid beta (Abeta) peptide is involved in the pathogenesis of AD, which is supported by the fact that Abeta overexpression or production of more aggregation-prone variants lead to early-onset dementia. LÄS MER