Sökning: "β"

Visar resultat 11 - 15 av 1506 avhandlingar innehållade ordet β.

  1. 11. Novel Regulators of the TGF-β Signaling Pathway

    Författare :Marcin Kowanetz; Aristidis Moustakas; Carl-Henrik Heldin; Caroline Hill; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; TGF-β; Smad; Id; EMT; cell cycle; SNF1LK; ubiquitin; degradation; signal transduction; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi;

    Sammanfattning : The transforming growth factor-β (TGF-β) superfamily consists of related multifunctional cytokines, which include TGF-βs, activins, and bone morphogenetic proteins (BMPs) and coordinate several biological responses in diverse cell types. The biological activity of TGF-β members is executed by transmembrane serine/threonine kinase receptors and intracellular Smad proteins. LÄS MER

  3. 12. The role of beta-blockade and anticoagulation therapy in traumatic brain injury

    Författare :Shahin Mohseni; Claes Juhlin; Örebro universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; traumatic brain injury; β-blockers; pre-injury β-blockade; race; ethnicity; mortality; anticoagulation; venous thromboembolic event; Medicine; Medicin;

    Sammanfattning : .... LÄS MER

  4. 13. Towards the Development of Photoswitchable β-Hairpin Mimetics

    Författare :Máté Erdélyi; Adolf Gogoll; Anders Karlén; John A. Robinson; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; β-hairpin; peptidomimetics; Sonogashira; NMR; photochemistry; microwave; peptide; palladium; Organisk kemi; Organic chemistry; Organisk kemi;

    Sammanfattning : Peptide secondary structure mimetics are important tools in medicinal chemistry, as they provide analogues of endogeneous peptides with new physicochemical and pharmacological properties. The β-hairpin motif has been shown to be involved in numerous physiological processes, among others in regulation of eucariotic gene transcription. LÄS MER

  5. 14. Epac2 signaling at the β-cell plasma membrane

    Författare :Ida Alenkvist; Anders Tengholm; Olga Göransson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; β-cell; insulin secretion; cAMP; Ca2 ; Epac; Rap; exocytosis; sulfonylurea; Medical Cell Biology; Medicinsk cellbiologi;

    Sammanfattning : Secretion of appropriate amounts of insulin from pancreatic β-cells is crucial for glucose homeostasis. The β-cells release insulin in response to glucose and other nutrients, hormones and neurotransmitters, which trigger intracellular signaling cascades, that result in exocytotic fusion of insulin-containing vesicles with the plasma membrane. LÄS MER

  7. 15. ATP Dynamics in Pancreatic α- and β-cells

    Författare :Jia Li; Anders Tengholm; Erik Gylfe; Hindrik Mulder; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; ATP; Ca2 ; β-cell; α-cell; SERCA; SOCE; muscarinic receptor; insulin secretion; glucagon secretion; Medical Cell Biology; Medicinsk cellbiologi;

    Sammanfattning : Glucose metabolism in pancreatic α- and β-cells is believed to regulate secretion of glucagon and insulin, respectively. In β-cells, ATP links glucose metabolism to electrical activity and insulin secretion. LÄS MER