Sökning: "wobble nucleoside"

Visar resultat 1 - 5 av 7 avhandlingar innehållade orden wobble nucleoside.

  1. 1. Function of wobble nucleoside modifications in tRNAs of Salmonella enterica Serovar Typhimurium

    Författare :Peng Chen; Glenn R. Björk; Paul Agris; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; tRNA; wobble nucleoside; frameshifting; translation; Molekylärbiologi; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Sammanfattning : Transfer RNA from all organisms has modified nucleosides and position 34 (the wobble position) is one of the most extensively modified positions. Some wobble nucleoside modifications restrict codon choice (e.g. 5-methylaminomethyl-2-thiouridine, mnm5s2U) while some extend the decoding capacity (e. LÄS MER

  3. 2. Formation and function of wobble uridine modifications in transfer RNA of Saccharomyces cerevisiae

    Författare :Bo Huang; Anders Byström; Monica Rydén-Aulin; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Transfer RNA; Modified nucleoside; Elongator complex; Wobble uridine; Decoding; Molecular biology; Molekylärbiologi;

    Sammanfattning : Transfer RNAs (tRNAs) act as adaptor molecules in decoding messenger RNA into protein. Frequently found in tRNAs are different modified nucleosides, which are derivatives of the four normal nucleosides, adenosine (A), guanosine (G), cytidine (C), and uridine (U). LÄS MER

  4. 3. Influence of wobble uridine modifications on eukaryotic translation

    Författare :Hasan Tükenmez; Anders Byström; Tracy Nissan; Sebastian Leidel; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Elongator is a conserved six subunit protein (Elp1p-Elp6p) complex that is required for the formation of ncm5 and mcm5 side chains at wobble uridines in transfer RNAs (tRNAs). Moreover, loss-of-function mutations in any gene encoding an Elongator subunit results in translational defects and a multitude of phenotypic effects. LÄS MER

  5. 4. Functional aspects of wobble uridine modifications in yeast tRNA

    Författare :Anders Esberg; Anders Byström; James T. Anderson; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular biology; Transfer RNA; Modified nucleosides; Elongator complex; Translation; Kluyveromyces lactis γ-toxin; Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Sammanfattning : Transfer RNAs (tRNA) function as adaptor molecules in the translation of mRNA into protein. These adaptor molecules require modifications of a subset of their nucleosides for optimal function. The most frequently modified nucleoside in tRNA is position 34 (wobble position), and especially uridines present at this position. LÄS MER

  7. 5. Wobble modifications and other features in transfer RNA important for decoding and reading frame maintenance

    Författare :Joakim Näsvall; Glenn Björk; Michael O'Connor; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Transfer RNA; Modified nucleosides; Decoding; Reading frame maintenance; Molecular biology; Molekylärbiologi;

    Sammanfattning : Transfer RNA (tRNA) is the adaptor molecule responsible for bringing the correct amino acid to the ribosome during protein synthesis. tRNA contains a number of modified nucleosides, which are derivatives of the four normal nucleosides. LÄS MER