Sökning: "valproic acid"

Visar resultat 11 - 15 av 17 avhandlingar innehållade orden valproic acid.

  1. 11. Epigenetic influence on cardiovascular protective mechanisms in vivo: explorations of t-PA release and extracellular vesicle genetic content

    Författare :Kristina Svennerholm; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; myocardial ischemia; epigenetics; histone deactylase inhibition; t-PA; extracellular vesicles; ischemic preconditioning;

    Sammanfattning : ABSTRACT Background: Ischemic heart disease is one of the leading causes of death globally. This thesis explores endogenous mechanisms protecting against myocardial ischemia in context of epigenetics (changes in gene activity not caused by changes in DNA sequences). LÄS MER

  3. 12. Genetic vulnerability, environmental exposures and neurodevelopmental disorders : clinical insights and in-vitro consequences

    Författare :Abishek Arora; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : An understanding of how different genetic backgrounds and environmental exposures interact and contribute to diverse medical conditions like neurodevelopmental disorders (NDDs), is key to better health outcomes. A considerable overlap exists in the underlying genetics and physiology, often leading to their co-diagnoses. LÄS MER

  4. 13. Possibilities of dried blood spots as a matrix in therapeutic drug monitoring of antiepileptic drugs in children

    Författare :Camilla Linder; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : For children with epilepsy, therapeutic drug monitoring (TDM) of antiepileptic drugs (AEDs) is essential for treatment. TDM monitoring requires two visits to a health care unit, first for collection of the blood sample before the morning dose and a few days later the family will travel once again to see the pediatrician. LÄS MER

  5. 14. On histone deacetylases in the epigenetic regulation of neural stem and cancer cell fate

    Författare :Karolina Wallenborg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Development of an organism requires correct spatial and temporal regulation of gene expression. Epigenetic regulation of gene expression has been shown to be an important part of many cellular events. Nucleosomes consist of two subunits of each core histone proteins H2A, H2B, H3, H4, and 146 base pairs of DNA, wrapped around the histones. LÄS MER

  7. 15. Metabolic drug interactions in man : methodological aspects on in vivo studies

    Författare :Ylva Böttiger; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :drug interactions; drug metabolism; cytochrome P450; therapeutic drug monitoring; omeprazole; ketoconazole; tolterodine; ropivacaine; sirolimus; diltiazem; lamotrigine; humans;

    Sammanfattning : The aim of this thesis was to investigate methodological aspects on in vivo metabolic drug interaction studies in man. Five pharmacokinetic studies in healthy persons or patients are presented. Together, they represent a set of model studies to evaluate the occurrence of, and extent of metabolic drug interactions in vivo. LÄS MER