Sökning: "sirolimus"

Hittade 3 avhandlingar innehållade ordet sirolimus.

1. 1. Metabolic drug interactions in man : methodological aspects on in vivo studies

   Författare :Ylva Böttiger; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :drug interactions; drug metabolism; cytochrome P450; therapeutic drug monitoring; omeprazole; ketoconazole; tolterodine; ropivacaine; sirolimus; diltiazem; lamotrigine; humans;

   Sammanfattning : The aim of this thesis was to investigate methodological aspects on in vivo metabolic drug interaction studies in man. Five pharmacokinetic studies in healthy persons or patients are presented. Together, they represent a set of model studies to evaluate the occurrence of, and extent of metabolic drug interactions in vivo. LÄS MER

3. 2. Natural killer cell development and function in the context of allogenic stem cell transplantation and cell therapy

   Författare :Alvaro Haroun-Izquierdo; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Natural killer (NK) cells play a crucial role in the control of viral infections and transformed, cancerous cells. These innate cells have high cytotoxic capacities and use a multitude of receptors to interact with neighbouring cells. LÄS MER

4. 3. From risk indices to reconstitution of immunity : studies of outcome-related factors in patients undergoing allogeneic hematopoietic stem cell transplantation

   Författare :Johan Karlsson Törlén; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Allogeneic hematopoietic stem cell transplantation (HSCT) is a potent immunotherapeutic procedure which has the possibility to cure otherwise lethal hematological diseases. Its usability in clinical practice is limited by tangible risks of detrimental transplantation-related complications. LÄS MER