Sökning: "tolerance education"

Visar resultat 21 - 25 av 51 avhandlingar innehållade orden tolerance education.

  1. 21. Natural killer cell education under conditions of perturbed sensing of MHC : studies in MHC-I mosaic and chimaeric mice

    Författare :Sadia Salam; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Natural killer (NK) cells are innate lymphocytes that play a role in infections, tumours and transplantation. Their activating and inhibitory receptors sense cell surface ligands on potential target cells. LÄS MER

  3. 22. NK cells and missing self recognition : genetic control, mhc class i dependent education and potential use in cancer therapy

    Författare :Stina L Wickström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : NK cells belong to the innate immune system and are important in the defense against virus infections and malignant cells. They mediate their effector functions via release of cytotoxic granules and by cytokine production which can influence the status of other (immune) cells. LÄS MER

  4. 23. Advancing cancer immunotherapy by exploring NK cell education, antibody targeting and tissue homing : stay tuned for directions reaching beyond the natural biology

    Författare :Caroline Leijonhufvud; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cancer immunotherapy is a fast-growing field. The natural killer (NK) cells’ innate ability to detect malignant cells and capacity to perform antibody-dependent cellular cytotoxicity (ADCC) together with low risk of inducing side effects makes these cells an attractive tool for cancer immunotherapy. LÄS MER

  5. 24. Cardiorespiratory fitness, insulin sensitivity, and perceptions of obesity treatment in obese children and adolescents

    Författare :Gunilla Morinder; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Adolescents; body composition; cardiorespiratory fitness; children; insulin sensitivity; obesity; phenomenography; physical activity; physical education classes; reproducibility; 6MWT;

    Sammanfattning : Background and Aims: The childhood obesity epidemic is accelerating throughout the world and is associated with long-term medical and psychosocial consequences. To gain knowledge for clinical practice and further research, the overall aims of this thesis were to explore and describe obese children s and adolescents physical fitness, participation in organized physical activity, and insulin sensitivity (SI). LÄS MER

  7. 25. Natural killer cell inhibitory and activating receptors : regulatory role in effector functions against normal and tumor cells

    Författare :Gustaf Vahlne; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Natural killer (NK) cells can mediate effector functions as cytokine production and degranulation dependent cytotoxicity against cells that have become aberrant by mutagenesis or by infection. As part of the innate immunity, the NK cells are most important in the direct early defense against infections, and also in indirect shaping of the later adaptive response. LÄS MER