Sökning: "the estrogen receptor α"

Visar resultat 21 - 25 av 37 avhandlingar innehållade orden the estrogen receptor α.

  1. 21. Reproductive function in male childhood cancer survivors

    Författare :Patrik Romerius; Malmö Reproduktionsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Childhood Cancer SurvivorsFertilityHypogonadismSperm DNA IntegrityAzoospermiaEstrogen Receptor alpha polymorphism;

    Sammanfattning : Childhood cancer (CC) survival rate has increased over the last couple of decades, today approaching 80%. Therefore more attention has been paid to late effects. One important issue for CC survivors (CCS) is impaired reproductive function. LÄS MER

  3. 22. Molecular dynamic studies of nuclear receptors ligand binding domain

    Författare :Sofia Burendahl; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Nuclear Receptors (NR) function as transcription factors that regulate genes that affect processes like reproduction, development and metabolism. The NRs are activated upon a given signal, which can be a ligand binding or a chemical modification. LÄS MER

  4. 23. Apoptosis, proliferation, and sex steroid receptors in endometrium and endometrial carcinoma

    Författare :Marju Dahmoun; Torbjörn Bäckström; Karin Boman; Stefan Cajander; Seija Grénman; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine; estradiol; progesterone; steroid receptors; apoptosis; proliferation; endometrial carcinoma; Ki-67; p53; immunohistochemistry; Medicin; Dermatology and venerology; clinical genetics; internal medicine; Dermatologi och venerologi; klinisk genetik; invärtesmedicin; medicin; Medicine;

    Sammanfattning : This thesis focuses on the involvement of apoptosis and proliferation in the mechanisms of menstruation and hormonal replacement therapy, HRT, as well as in the mechanisms of progesterone therapy in endometrial carcinoma. The aim of the first study was to investigate endometrium for 4 days before and for 2 days during menstruation. LÄS MER

  5. 24. Molecular studies of dyslexia : regulation and function of DYX1C1

    Författare :Kristiina Tammimies; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Developmental dyslexia is a specific reading disability characterized by unexpected difficulty in reading and writing despite adequate intelligence, education, normal senses and social environment. It is the most common childhood learning disorder affecting five to ten percent of school age children and it is more common among boys than girls. LÄS MER

  7. 25. CYP2C19 and CYP2C9 : new aspects of pharmacogenetics and transcriptional regulation

    Författare :Jessica Mwinyi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cytochrome P450s (CYPs) are responsible for approximately 75% of the phase I-dependent drug metabolism. Several important polymorphisms in these enzymes are known to significantly affect the individual drug response. LÄS MER