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  1. 1. Splice site selection in Saccharomyces cerevisiae pre-mRNA splicing

    Författare :B G Mattias Luukkonen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Pre-mRNA splicing is the process by which intervening sequences (introns) are removed from the coding sequences (exons) resulting in a mature messenger-RNA (mRNA). Splicing takes place in a large ribonucleoprotein complex termed the spliceosome, composed of several protein components and the five small nuclear RNAs (snRNAs) U I, U2, U4, U5 and U6. LÄS MER

  3. 2. Design and application of RNA therapeutics for splice site mutations

    Författare :Burcu Bestas; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Precursor messenger RNA splicing is one of the most fundamental and complex mechanisms in eukaryotes. Over 90% of the human genes undergo alternative splicing, which is essential for the regulation of gene expression. A dynamic RNA-protein complex called the spliceosome catalyzes splicing. LÄS MER

  4. 3. Understanding the Noise : Spliceosomal snRNA Profiling

    Författare :Lei Liu Conze; Anders Virtanen; Lars Wieslander; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; ncRNA; snRNA; U1; splice site; alternative splicing; high-throughput sequencing; 454; SNP; Molekylär cellbiologi; Molecular Cellbiology;

    Sammanfattning : The concept of the gene has been constantly challenged by new discoveries in the life sciences. Recent challenging observations include the high frequency of alternative splicing events and the common transcription of non-protein-coding-RNAs (ncRNAs) from the genome. The latter has long been considered noise in biological systems. LÄS MER

  5. 4. Computational Approaches to the Identification and Characterization of Non-Coding RNA Genes

    Författare :Pontus Larsson; Anders Virtanen; Leif Kirsebom; Stephen Mount; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; ncRNA; snRNA; U1; splice site; alternative splicing; Dictyostelium; nucleotide composition; partial sums; Bioinformatics; Bioinformatik;

    Sammanfattning : Non-coding RNAs (ncRNAs) have emerged as highly diverse and powerful key players in the cell, the range of capabilities spanning from catalyzing essential processes in all living organisms, e.g. protein synthesis, to being highly specific regulators of gene expression. LÄS MER

  7. 5. Regulation of alternative Pre-mRNA splicing : positive and negative control of adenovirus 3' splice site selection

    Författare :Oliver Mühlemann; Uppsala universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : .... LÄS MER