Sökning: "Lars Wieslander"

Visar resultat 1 - 5 av 7 avhandlingar innehållade orden Lars Wieslander.

  1. 1. Nuclear Organization of Gene Expression in Adenovirus Infected Cells

    Författare :Anders Aspegren; Lars Wieslander; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Adenovirus; mRNA; transport; IGCs; E434kDa; E1B55kDa; NES; snRNP; Genetik; Clinical genetics; Klinisk genetik; Medical Genetics; medicinsk genetik;

    Sammanfattning : Adenovirus infected cells provide a good model system for studying nuclear organization during RNA production and transport. This thesis is focused on the dynamic organization of splicing factors during the late phase of Adenovirus infection in HeLa cells, the nuclear localization of viral RNA, and the pathway used for viral RNA transport to the cytoplasm. LÄS MER

  3. 2. Understanding the Noise : Spliceosomal snRNA Profiling

    Författare :Lei Liu Conze; Anders Virtanen; Lars Wieslander; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; ncRNA; snRNA; U1; splice site; alternative splicing; high-throughput sequencing; 454; SNP; Molekylär cellbiologi; Molecular Cellbiology;

    Sammanfattning : The concept of the gene has been constantly challenged by new discoveries in the life sciences. Recent challenging observations include the high frequency of alternative splicing events and the common transcription of non-protein-coding-RNAs (ncRNAs) from the genome. The latter has long been considered noise in biological systems. LÄS MER

  4. 3. "Det är inte mig det är fel på, det är huset" : en studie av prognosfaktorer och bemötande med fokus på sjuka hus-syndromet

    Författare :Berit Edvardsson; Berndt Stenberg; Lars Weinehall; Gunilla Wieslander; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; SBS; byggnadsrelaterad ohälsa; uppföljning; prognos; självbild; coping; personlighet; intervjuer; bemötande; Occupational and Environmental Medicine; arbets- och miljömedicin; Epidemiology; epidemiologi; folkhälsa; Public health;

    Sammanfattning : Bakgrund: Sick Building Syndrome, SBS, är fortfarande 2015 ett tillstånd som vållar mycket diskussion. Symtomen kan grupperas i slemhinnesymtom, hudsymtom och allmänna symtom. I definitionen ingår att personen/ personerna som fått symtom har exponerats för dålig inomhusluft i en speciell byggnad. LÄS MER

  5. 4. Molecular Cloning and Functional Characterization of Factors Involved in Post-transcriptional Gene Expression

    Författare :Shao-Bo Jin; Lars Wieslander; Maria Carmo-Fonseca; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; gene expression; pre-mRNA processing; pre-rRNA processing; Molecular biology; Molekylärbiologi;

    Sammanfattning : Gene expression in the eukaryotic cell is a fundamental cellular process, which consists of several distinct steps but extensively coupled to each other. From site of transcription in the nucleus to the cytoplasm, both mRNA and rRNA are associated with a proper set of proteins. LÄS MER

  7. 5. Nucleolar Ribosome Assembly

    Författare :Fredrik Lackmann; Lars Wieslander; Denis Lafontaine; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Ribosome biogenesis; RNA; Nucleolus; Molecular Biology; molekylärbiologi;

    Sammanfattning : Ribosomes are macromolecular machines that are responsible for production of every protein in a living cell. Yet we do not know the details about how these machines are formed. The ribosome consists of four RNA strands and roughly 80 proteins that associate with each other in the nucleolus and form pre-ribosomal complexes. LÄS MER