Sökning: "radiologi tomografi Klinisk fysiologi medical instrumentation tomography radiology Clinical physics technetium-99m radionuclide imaging radioactive aerosol powder inhaler pharmacokinetics mucociliary clearance lung deposition gamma scintigraphy inhalation deposition modelling drug absorption absorption enhancer aerosol medicinsk instrumentering Physiology Fysiologi"
Hittade 1 avhandling innehållade orden radiologi tomografi Klinisk fysiologi medical instrumentation tomography radiology Clinical physics technetium-99m radionuclide imaging radioactive aerosol powder inhaler pharmacokinetics mucociliary clearance lung deposition gamma scintigraphy inhalation deposition modelling drug absorption absorption enhancer aerosol medicinsk instrumentering Physiology Fysiologi.
1. Deposition and absorption of inhaled drugs
Sammanfattning : Main objectives of this thesis were to evaluate a gamma scintigraphic method used to quantify drug aerosol deposition in the lung, to investigate the influence of two aerosol inhalation parameters on the distribution of inhaled dry powder within the airways, to assess pulmonary absorption kinetics and bioavailability of an inhaled hydrophilic solute in relation to site of deposition, and to assess the influence of a surface active agent (sodium taurocholate, a bile salt) on the deposition and absorption of an inhaled hydrophilic solute. Repeated planar gamma scintigraphy was found to provide the same information on total pulmonary drug deposition as an independent method that involved assessments of urinary drug recovery after blockage of gastrointestinal drug absorption when all of the critical parts of the methodological procedures were accurately and meticulously executed. LÄS MER
