Sökning: "progenitor domains"

Visar resultat 11 - 15 av 19 avhandlingar innehållade orden progenitor domains.

  1. 11. Cryo-electron tomography of individual protein molecules

    Författare :Sara Sandin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Cryo-Electron Microscopy; Cryo-Electron Tomography; Protein Conformation; Antibodies; Immunoglobulin G; Glucocorticoid Receptor; Hepatocyte Growth Factor Scatter Factor; Receptor Tyrosine Kinase MET;

    Sammanfattning : Averaging methods of determining structure, such as X-ray diffraction, do not preserve information about the flexibility of molecules. Cryo-electron tomography allows us to reconstruct individual hydrated objects. LÄS MER

  3. 12. The enzymatic machinery of leukotriene biosynthesis : Studies on ontogenic expression, interactions and function

    Författare :Tobias Strid; Sven Hammarström; Mats Söderström; Ralf Morgenstern; Linköpings universitet; []
    Nyckelord :;

    Sammanfattning : Leukotrienes (LTs) are biologically active arachidonic acid (AA) derivatives generated by the 5-lipoxygenase (5-LO) pathway. They are produced by myeloid cells. 5-LO converts AA to LTA4 in cooperation with 5-LO activating protein (FLAP). LTA4 is converted to LTB4, by LTA4-hydrolase (LTA4H) or to LTC4 by LTC4-synthase (LTC4S). LÄS MER

  4. 13. Morphogen interpretation in the developing nervous system

    Författare :Sanja Kurdija; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Development of the central nervous system relies on the generation of specialized cell types in a tightly controlled spatial and temporal order from neural progenitor cells. Morphogen molecules, secreted by defined sources, spatially organize neural progenitors by inducing discrete expression patterns of cell fate determinant genes in a concentration-dependent manner. LÄS MER

  5. 14. Mechanisms of cell diversification

    Författare :Christopher Winston Uhde; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cell identity and function is determined by the intrinsic wiring of the gene regulatory network that endows progenitors with the competence to respond appropriately to extrinsic cues in a spatiotemporally-dependent manner. One such class of cues, morphogens, instruct cells in their identity by virtue of a concentration gradient, but how this is interpreted at gene regulatory levels to result in sharp and robust boundaries of gene expression is poorly understood. LÄS MER

  7. 15. Genetic mechanisms behind cell specification in the Drosophila CNS

    Författare :Magnus Baumgardt; Stefan Thor; Angela Giangrande; Linköpings universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Drosophila melanogaster; nervous system development; cell specification; stem cells; cell proliferation; combinatorial coding; feedforward loop; Developmental biology; Utvecklingsbiologi;

    Sammanfattning : The human central nervous system (CNS) contains a daunting number of cells and tremendous cellular diversity. A fundamental challenge of developmental neurobiology is to address the questions of how so many different types of neurons and glia can be generated at the precise time and place, making precisely the right connections. LÄS MER