Sökning: "polyplexes"

Hittade 4 avhandlingar innehållade ordet polyplexes.

  1. 1. Functional Cyclic Carbonate Monomers and Polycarbonates : Synthesis and Biomaterials Applications

    Författare :Jonas Mindemark; Tim Bowden; Andrew Dove; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; DNA condensation; gene delivery; ionomers; polyplexes; self-assembly; amphiphiles; biodegradable; biological applications of polymers; transfection; cyclic carbonate monomers; polycarbonates; semicrystalline polymers; click chemistry; triazoles; cycloaddition; Kemi med inriktning mot polymerkemi; Chemistry with specialization in Polymer Chemistry;

    Sammanfattning : The present work describes a selection of strategies for the synthesis of functional aliphatic polycarbonates. Using an end-group functionalization strategy, a series of DNA-binding cationic poly(trimethylene carbonate)s was synthesized for application as vectors for non-viral gene delivery. LÄS MER

  3. 2. Chitosan Polyplexes as Non-Viral Gene Delivery Systems : Structure-Property Relationships and In Vivo Efficiency

    Författare :Magnus Köping-Höggård; Per Artursson; Jean-Paul Behr; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutics; gene therapy; gene delivery; non-viral; polyplex; chitosan; chitosan oligomers; polyethylenimine; plasmid DNA; lung; Galenisk farmaci; Pharmaceutics; Galenisk farmaci;

    Sammanfattning : The subject of this thesis was to develop and optimize delivery systems for plasmid DNA (pDNA) based on biocompatible polymers, in particular chitosan, suitable for non-viral gene therapy. At the onset of this thesis, studies had reported conflicting results on the efficiency of chitosan-based gene delivery systems. LÄS MER

  4. 3. Delivery of gene-regulating agents : internalization mechanisms and novel vectors

    Författare :Per Lundin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The sequencing of the human genome was expected to generate a veritable explosion of therapeutics for regulation of gene function, either through modulation of gene expression or through the replacement of defect genes. However, nucleic acid-based pharmacological agents suffer from issues of low bioavailability and unfavorable pharmacokinetics, wherefore these prospects have not yet been realized. LÄS MER

  5. 4. Round window membrane and delivery of biologically active agents into the cochlea

    Författare :Amanj Saber; Mats Ulfendahl; Lars Lundman; Karolinska Institutet; Karolinska Institutet; Sweden Stockholm Karolinska Institutet Department of Clinical Neoruscience; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Round window membrane; sodium hyaluronate; chitosan; local cochlear drug delivery and gene delivery; Oto-rhino-laryngologi; Oto-Rhino-Laryngology; Biology; Biologi; Round window membrane; sodium hyaluronate; chitosan; local cochlear drug delivery and gene delivery;

    Sammanfattning : Establishing efficient methods for local administration of drugs to the inner ear has great clinical relevance for the management of inner ear disorders. However, the administration route remains a critical issue. LÄS MER