Sökning: "plasmid DNA"

Visar resultat 1 - 5 av 109 avhandlingar innehållade orden plasmid DNA.

  1. 1. Development of benzoquinoquinoxaline derivatives as triplex-specific probes : Recognition of DNA structures at repeats sequences

    Detta är en avhandling från Stockholm : Department of Molecular Biology and Functional Genomics, Stockholm University

    Författare :Helen Bergquist; Stockholms universitet.; [2011]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Triplex; H-DNA; BQQ; BQQ-OP; BQQ-Bodipy; triplet repeat; DNA; non-B-DNA; pkd1; frataxin; Friedreich s ataxia; NATURAL SCIENCES Biology Cell and molecular biology Molecular biology; NATURVETENSKAP Biologi Cell- och molekylärbiologi Molekylärbiologi; Molecular Biology; molekylärbiologi;

    Sammanfattning : Repeat sequences are associated with several human diseases, such as Friedreich’s ataxia, polycystic kidney disease and cancer. These sequences can form non-B-DNA structures, including triplex (H-DNA) DNA, and are associated with genomic instability and altered gene expression. LÄS MER

  2. 2. Novel Chromatography Matrices for Fast Isolation of Plasmid DNA

    Detta är en avhandling från Division of Pure and Applied Biochemistry, Lund University, Sweden

    Författare :Peter Tiainen; Lunds universitet.; Lund University.; [2007]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biokemisk teknik; Polymer technology; biopolymers; Polymerteknik; Biotechnology; Bioteknik; Biochemical technology; Plasmid recovery.; Composite materials; Kompositmaterial; Coating and surface treatment; Skikt och ytbehandling; Superporous agarose; Silica fibres; Plasmid purification; Anion-exchange matrices;

    Sammanfattning : As new therapeutic areas in which genetic material is employed, i.e. gene therapy and DNA vaccination, are expanding, a substantial increase in the demand for gene vectors, e.g. LÄS MER

  3. 3. Specific Precipitation of Biomolecules Using Synthetic Polymers

    Detta är en avhandling från Per-Olof Wahlund, Dept. of Biotechnology, Lund University

    Författare :Per-Olof Wahlund; Lunds universitet.; Lund University.; [2003]
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Biotechnology; Polymerteknik; RNA; plasmid DNA; DNA; polyelectrolyte complexes; synthetic polymers; precipitation; affinity precipotation; Bioteknik; Polymer technology; biopolymers;

    Sammanfattning : Purification is a very important stage in biotechnological processes. The traditionally used precipitation techniques are generally nonspecific and thus one or more chromatographic steps are normally required. There is thus a need for new approaches to improve existing techniques. LÄS MER

  4. 4. Primary Sjögren's Syndrome: Studies of DNA damage responses and autoantibodies

    Detta är en avhandling från Department of Laboratory Medicine, Lund University

    Författare :Gunnel Henriksson; Lunds universitet.; Lund University.; [2001]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; autoantibodies; 18 ; t 14; cell cycle; p53; DNA-PK; DNA-binding protein; hypermutation; Sjögren s syndrome; DNA damage; anti-CD4 antibodies; Microbiology; bacteriology; virology; mycology; Mikrobiologi; bakteriologi; virologi; mykologi;

    Sammanfattning : Popular Abstract in Swedish Sjögrens syndrom är en autoimmun sjukdom, vilket betyder att immunsystemet felreagerar och angriper kroppens egen vävnad. Nittio procent av dem som får diagnosen är kvinnor, av vilka de flesta är mellan 40 och 60 år. LÄS MER

  5. 5. DNA vaccines and bacterial DNA in immunity

    Detta är en avhandling från Stockholm : Karolinska Institutet, Microbiology and Tumor Biology Center (MTC)

    Författare :Lisa Charlotta Bandholtz; Karolinska Institutet.; Karolinska Institutet.; [2002]
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; DNA vaccine; CpG DNA; antimicrobial peptides C. pneumoniae; Shigella spp;

    Sammanfattning : This thesis describes DNA-based vaccination and the importance of bacterial DNA in different immunological perspectives. Intranasal (i.n.) DNA vaccination utilizing a plasmid encoding the chlamydial heat shock protein 60 (p-hsp-60) generated lower bacterial burden and reduced pathology in the lungs of mice after subsequent infection with C. LÄS MER