Sökning: "parathyroid hormone-related protein"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden parathyroid hormone-related protein.

1. 1. New proteins in Ca2+ regulation : parathyroid hormone-related protein and a Ca2+ sensor molecule

   Författare :Per Hellman; Uppsala universitet; []
   Nyckelord :MEDICINE; MEDICIN;

   Sammanfattning : .... LÄS MER

3. 2. Parathyroid hormone-related protein (PTHrP), calcium and human osteoblast-like cells

   Författare :Jon A Tsai; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :hOB cells; PTHrP; cAMP; IGFs; IGFBPs; IL-1ß; TGF-ß; [Ca 2 ]i; [Ca2 ]O;

   Sammanfattning : Parathyroid hormone-related protein (PTHrP) may cause humoral hypercalcernia of malignancy (HHM) when overproduced by malignant tumors, but is also produced in lower amounts under normophysiological conditions in practically all cell types, including osteoblasts. One of the aims of the present study was to investigate interactions between PTHrP and osteoblasts, to elucidate bone-regulating functions of PTHrP. LÄS MER

4. 3. Physiological and clinical studies of calcium-regulating hormones calcitonin and parathyroid hormone-related protein

   Författare :Haiqin Rong; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :bone metabolism; breast cancer; calcitonin; calcium; exercise; lanthanide; milk; neonate; osteoporosis; parathyroid hormone-related protein; parturition; polymerase chain reaction; time-resolved fluorometry;

   Sammanfattning : The present studies were performed to elucidate several physiological and clinical questions of calcitonin (CT) and parathyroid hormone-related protein (PTHrP) such as: a) Does age influence the basal and calcium-stimulated levels and circulating molecular forms of CT in healthy females? b) Are osteoporotic patients lacking circulating monomeric CT? c) How is salmon CT (sCT) absorbed and cleared during treatment of diseases? d) Is there any effect of acute physical activity on circulating CT, PTH, PTHrP and bone metabolic markers? e) Is there an absorbance of PTHrP in milk by the neonate? and f) Are there any interactions between CT and PTHrP? In addition, by use of time-resolved dissociation and enhancement lanthanide fluorometry, the effort was put to develop two-site immunofluorometric assays (IFMA) for sCT and PTHrP as well as a quantitative competitive PCR (QC-PCR) for measuring PTHrP mRNA and use these methods in some of the investigations. Heterogeneity of CT forms in serum was disclosed after immunoextraction, fast protein liquid chromatography (FPLC) and radioimmunoassay (RIA) in healthy females and osteoporotic patients. LÄS MER

5. 4. Prognostic factors in renal cell carcinoma : evaluation of erythropoietin and its receptor, carbonic anhydrase IX, parathyroid hormone-related protein and osteopontin

   Författare :Karin Papworth; Torgny Rasmuson; Börje Ljungberg; Kjell Grankvist; Sten Nilsson; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Renal cell carcinoma; EPO; EPO-R; CA IX; PTHrP; OPN; prognosis; Oncology; Onkologi; onkologi; Oncology;

   Sammanfattning : A prognostic factor is a marker or a feature that can be used to estimate the risk of recurrence of disease, metastatic spread and clinical outcome. Despite intensive search for more sophisticated markers in renal cell carcinoma (RCC), few have added prognostic information to earlier described factors like stage of disease, nuclear grade, tumour type, and in metastatic disease; performance status, anaemia, hypercalcaemia and increased erythrocyte sedimentation. LÄS MER

7. 5. Thyroid hormone receptors and the regulation of bone physiology

   Författare :Jenny Kindblom; Göteborgs universitet; []
   Nyckelord :;

   Sammanfattning : The aim of the studies in this thesis was to investigate the role of thyroid hormone receptors in bone physiology. Thyroid hormone signals through its receptors, the TRs, and has profound effects on bone development and metabolism, as demonstrated in hypo- and hyperthyroidism. LÄS MER