Sökning: "jejunum"

Visar resultat 1 - 5 av 45 avhandlingar innehållade ordet jejunum.

  1. 1. Jejunal control of glucose homeostasis in the human body

    Författare :Erik Elebring; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; glucose homeostasis; ketogenesis; jejunum;

    Sammanfattning : Background: The prevalence of obesity and type-2 diabetes mellitus (T2DM) have risen dramatically over the last decades, and are major threats to the human health. Obesity, and also T2DM, is treated with lifestyle modifications, medications or by bariatric surgery, with varying success. LÄS MER

  3. 2. Luminal Hypotonicity and Duodenal Functions : An Experimental Study in the Rat

    Författare :Liselotte Pihl; Olof Nylander; Gunnar Flemström; Mats Jodal; Uppsala universitet; []
    Nyckelord :Physiology; luminal alkalinization; mucosal permeability; osmolality; cyclooxygenase-2; rat; duodenum; jejunum; motility; enteric nervous system; Fysiologi;

    Sammanfattning : After drinking water, the fluid quickly leaves the stomach thereby creating a hypotonic luminal environment in the duodenum. This in turn constitutes a potential threat to the integrity of the duodenal epithelium. It therefore seems highly likely that luminal hypotonicity activates physiological mechanisms that aim to increase luminal osmolality. LÄS MER

  4. 3. Membrane transport and the human small intestine : Relation to mucosal protection, intestinal anaphylaxis and nitric oxide

    Författare :Tina W. Knutson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; albumin; bicarbonate secretion; carbonic anhydrase; dopamine; duodenum; histamine; humans; hyaluronan; intestinal anaphylaxis; intestinal obstruction; jejunum; lidocaine; LOC-I-GUT; nitecapone; nitric oxide; potential difference; prostaglandins; segmental intestinal perfusion; Kirurgi; Surgery; Kirurgi; anestesiologi; Anaesthesiology;

    Sammanfattning : The tightly adherent monolayer of epithelial cells that line the luminal side of the intestine provides a dynamic and highly regulated barrier to the passive and active transport of ions, water and macromolecules. Cathecol-O-methyl transferase inhibition prevents tissue degradation of catecholaminesincluding dopamine and intracellular carbonic anhydrase activity is an important regulator of ion and water transport in the small intestine. LÄS MER

  5. 4. Angiotensin II receptors in the small intestine. Expression analyses and functional considerations

    Författare :Emma Spak; Göteborgs universitet; []
    Nyckelord :renin-angiotensin system; angiotensin II; AT1; AT2; small intestine; jejunum; hypovolemia; small bowel transplantation; smooth muscle; contractility;

    Sammanfattning : .... LÄS MER

  7. 5. Intestinal barriers to oral drug absorption: Cytochrome P450 3A and ABC-transport proteins

    Författare :Helena Engman; Per Artursson; Hans Lenernäs; Heyo K Kroemer; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutics; oral drug delivery; bioavailability; human jejunum; Caco-2; ABC-transporter; P-glycoprotein; CYP3A; Galenisk farmaci; Pharmaceutics; Galenisk farmaci;

    Sammanfattning : The subject of this thesis was to study two intestinal barriers to oral drug bioavailability, drug efflux proteins of the ABC-transporter family, and in particular ABCB1/P-glycoprotein (Pgp), and the drug metabolizing enzyme cytochrome P450 (CYP) 3A4. At the onset of this thesis, similarities between CYP3A4 and Pgp in terms of their tissue distribution and gene regulation, along with overlapping substrate specificities, had generated the hypothesis that CYP3A4 and Pgp may have a complementary function and thus form a coordinated intestinal barrier to drug absorption and gut wall metabolism. LÄS MER