Sökning: "nucleotide modification"

Visar resultat 11 - 15 av 25 avhandlingar innehållade orden nucleotide modification.

  1. 11. Voltage sensor movements in shaker and HCN channels

    Författare :Roope Männikkö; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Voltage-gated ion channels are crucial for electrical signaling in living organisms. They are composed of four similar subunits with six transmembrane α-helices, S1-S6. Each subunit contains a voltage-sensing domain, S1-S4, and an ion-conducting pore domain, S5-S6. LÄS MER

  3. 12. Development of mathematical modelling for the glycosylation of IgG in CHO cell cultures

    Författare :Liang Zhang; Véronique Chotteau; Michael J. Betenbaugh; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Chinese hamster ovary cells; glycosylation; IgG; mathematical modelling; experimental design; perfusion; carbon sources; GReBA; Bayesian network; probabilistic graphic model; Bioteknologi; Biotechnology;

    Sammanfattning : Chinese hamster ovary (CHO) cells are the most popular expression system for the production of biopharmaceuticals. More than 80% of the approved monoclonal antibodies (mAbs) or immunoglobulin G (IgG) are produced with these cells. Glycosylation is a usual post- translational modification important for therapeutic mAbs. LÄS MER

  4. 13. Oxidized nucleotides as a predictor of radiation sensitivity

    Författare :Ali Pour Khavari; Siamak Haghdoost; Marie Öhman; Anders Nilsson; Bo Stenerlöw; Neus Visa; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; 8-oxo-dG; Radiation; Sensitivity; Oxidized; Nucleotides; ROS; NOS; molekylär biovetenskap; Molecular Bioscience;

    Sammanfattning : The direct and indirect effects of IR can lead to DNA damage and activation of DNA repair. The indirect effects of ionizing radiation mediated by reactive oxygen species (ROS) which produced through radiolysis of water and if not taken care of by the antioxidant system, can also give rise to oxidative stress. LÄS MER

  5. 14. Glucosyltransferase toxins from clostridia : molecular interactions with cells

    Författare :Esteban Chaves Olarte; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : An enzymatic activity was recently described for the group of Large Clostridial Cytotoxins (LCTs). This activity is glucosyltransfer and consists in the covalent addition of glucose, from UDP-glucose (UDP-Glc) to threonine 35 of small GTPases of the Rho subfamily. LÄS MER

  7. 15. Studies on natural antisense RNAs and microRNAs

    Författare :Omid Reza Faridani; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Regulatory RNAs are found in all kingdoms of life and involved in regulation of gene expression at various steps including RNA splicing, editing, stability, modification, export, translation and chromatin remodelling. A large number of regulatory RNAs have been described recently. LÄS MER