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Visar resultat 1 - 5 av 35 avhandlingar som matchar ovanstående sökkriterier.
1. Acylated cell-penetrating peptides for nucleic acid delivery
Sammanfattning : In recent decades many new methods have been developed to cure or treat genetical disorders such as cancer, viral infections or inheritable diseases. The problem is that the nucleic acids and their synthetic analogs, oligonucleotides, are not able to cross the cell membrane due to their physicochemical properties like high negative charge and size. LÄS MER
2. Nucleic acid based therapeutic approaches
Sammanfattning : Nucleic acid therapy comprises several approaches based on nucleic acid as the active therapeutic component to treat human disease. Antisense and short interfering RNA (siRNA) are two gene-silencing techniques in this category. Based on nucleic acid sequence recognition both techniques inhibit gene expression. LÄS MER
3. Cell-penetrating peptides targeting glioblastomas for nucleic acid delivery in the blood-brain barrier model
Sammanfattning : Glioblastoma multiforme is the most aggressive form of malignant brain tumor with poor prognosis. The efficacy of brain cancer treatment by chemotherapeutics is limited by the blood-brain barrier (BBB) which allows less than 2% of the small molecules and blocks almost all the macromolecules to transport into the brain. LÄS MER
4. Characterization of nucleic acid delivery with fatty acid modified cell-penetrating peptide nanoparticle formulations
Sammanfattning : Recent advances with techniques used for manipulating gene expression have brought us to an era where various gene therapeutic approaches are becoming common therapeutic tools for many previously incurable diseases. The main factor impeding the wider translation of gene therapy is that the active pharmaceutical ingredients used for interfering with gene expression are based on nucleic acids and synthetic oligonucleotides and such molecules do not readily reach their intracellular targets due to their physicochemical properties and therefore they require delivery vectors to cross the cell membrane. LÄS MER
5. Nucleic acid in gene delivery and gene regulation
Sammanfattning : The concept of gene therapy, initially attributed to a technology that would allow the correction of inherited genetic disease, has evolved over the years. The realization of the immense technical hurdles to achieve genetic correction led to a broadening of the concept now including the transfer of genetic material whose expression will counteract, mitigate or revert a disease phenotype. LÄS MER
