Sökning: "high-grade serous ovarian cancer"

Visar resultat 1 - 5 av 13 avhandlingar innehållade orden high-grade serous ovarian cancer.

  1. 1. Hunting a Silent Killer. Biomolecular Approaches in Ovarian Cancer

    Författare :Nicolai Arildsen; Bröstcancer-genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Ovarian cancer; Molecular biology; genetic variant; TP53 mutation; early detection; Drug Screening Assays; Antitumor; bioinformatics; next generation sequencing; NGS; prognostic and predictive biomarkers; ovarian clear cell cancer; high-grade serous ovarian cancer;

    Sammanfattning : Ovarian cancer is a heterogeneous disease and recent advances in improving patient outcome havebeen limited. It is estimated that a woman’s risk of developing ovarian cancer during her lifetime is about 1 in 70, making it a frequently occurring cancer type in women. LÄS MER

  3. 2. Mechanisms for immune escape in epithelial ovarian cancer

    Författare :Pernilla Israelsson; Ulrika Ottander; Lucia Mincheva-Nilsson; Eva Lundin; Ivan Nagaev; Karin Sundfeldt; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; human; ovarian cancer; high-grade serous cancer; EOC; HGSC; HGSOC; tumor microenvironment; immune escape; immune suppression; cytokines; exosomes; NKG2D; MICA B; ULBP1-3; DNAM-1; surgery; obstetrik och gynekologi; Obstetrics and Gynaecology;

    Sammanfattning : Tumors develop mechanisms to subvert the immune system, constituting immune escape. Epithelial ovarian cancer (EOC), the deadliest of all gynecological malignancies, uses a variety of mechanisms to undermine immune surveillance, aiding its establishment and metastatic spreading. LÄS MER

  4. 3. Impact of pregnancies on ovarian cancer : Risk, prognosis and tumor biology

    Författare :Camilla Sköld; Ingrid Glimelius; Karin Stålberg; Anthoula Koliadi; Gunilla Enblad; Annika Idahl; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Epithelial ovarian cancer; non-epithelial ovarian cancer; reproductive history; parity; risk factor; survival; progesterone receptor;

    Sammanfattning : Ovarian cancer is the most lethal gynecological malignancy. The etiology is complex and not fully understood, partly since ovarian cancer is not one distinct disease, but rather several histologically and clinically different subtypes. LÄS MER

  5. 4. Immunohistochemical and molecular studies on ovarian cancer progression and prognosis

    Författare :Björn Nodin; Tumörmikromiljö; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Epithelial ovarian cancer; prognostic and predictive biomarkers; tissue microarrays; androgen receptor; RBM3; Chek1; Chek2; MCM3; Dachshund 2; SATB1; KRAS mutation;

    Sammanfattning : Epithelial ovarian cancer (EOC) is the most lethal malignancy of the female reproductive tract. Due to vague symptomatology, the majority of EOC patients are diagnosed in advanced clinical stages with poor survival rates, despite improvements in surgical techniques and the advent of targeted therapeutics. LÄS MER

  7. 5. Novel biomarkers associated with histotype and clinical outcome in early-stage ovarian carcinoma

    Författare :Hanna Engqvist; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ovarian carcinoma; histotype-specific diagnosis and prognosis; molecular biomarker; outcome prediction; integrative analysis;

    Sammanfattning : Ovarian cancer is a collective name for multiple malignancies deriving from or involving the ovary, mainly comprising five histotypes of epithelial origin (clear-cell (CCC), endometrioid (EC), high-grade serous (HGSC), low-grade serous (LGSC), and mucinous carcinomas (MC)) with varying clinical (e.g. LÄS MER