Sökning: "PPARa"

Visar resultat 1 - 5 av 11 avhandlingar innehållade ordet PPARa.

  1. 1. Growth hormone and PPARa in the regulation of lipoprotein metabolism

    Författare :Daniel Lindén; Göteborgs universitet; []
    Nyckelord :growth hormone; insulin; fatty acids; PPARa; apolipoprotein B; VLDL; mRNA editing;

    Sammanfattning : In humans, apolipoprotein B (apoB)-100 is produced in the liver and apoB-48 is formed in the intestine. In the rat, however, the two forms of apoB are produced in the liver, leading to the formation of VLDL consisting of either apoB-48 or apoB-100. LÄS MER

  3. 2. Growth hormone regulation of LFABP and PPARa. Genes involved in hepatic lipid metabolism

    Författare :Linda Carlsson; Göteborgs universitet; []
    Nyckelord :Growth hormone; fatty acids; rat; hepatocyte; LFABP; C EBPa; PPARa;

    Sammanfattning : Growth hormone (GH) is known to have several important effects in the control of metabolism. The aim of these studies was to investigate how GH regulates genes involved in fatty acid transport and metabolism in the liver and the interaction between GH and fatty acids in this regulation. LÄS MER

  4. 3. Regulation of intracellular signaling events that modulate insulin action

    Författare :Silvia Gogg; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; insulin; insulin resistance; EGF; Gab 1; insulin receptor substrate; PI3-kinase; ; Thiazolidinediones; PPARã; insulin signaling; glucose transport; adipose tissue; â-cell.;

    Sammanfattning : Insulin regulates several mechanisms of fundamental importance to the body involving glucose, fat andprotein metabolism. Insulin resistance in skeletal muscle, liver and adipose tissue promotes an increaseddemand for insulin secretion. LÄS MER

  5. 4. Characterization of peroxisome proliferator-activated receptor alpha (PPARa) regulated acyl-CoA thioesterases involved in lipid metabolism

    Författare :Mary C Hunt; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Acyl-CoA thioesterase; acyl-CoA; peroxisome proliferator-activated receptor alpha; coenzyme A; bile acid metabolism; lipid metabolism.;

    Sammanfattning : The peroxisome proliferator-activated receptor alpha (PPARalpha) is a key nuclear receptor in the control of lipid metabolism. Target genes for PPARalpha include many enzymes involved in the oxidation of fatty acids in mitochondria and peroxisomes. LÄS MER

  7. 5. Novel radiation targets in the endothelium and heart muscle

    Författare :Venkata Ramesh Yentrapalli; Siamak Haghdoost; William F. Morgan; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Ionizing radiation; Endothelial cells; Senescence; Cardiovascular disease; Proteomics; molekylärgenetik; Molecular Genetics;

    Sammanfattning : Worldwide, people are being exposed to natural and man-made sources of radiation. Epidemiological studies have shown an increased risk of vascular diseases in populations that have been exposed to ionizing radiation. Vascular endothelium is implicated as one of the targets for radiation leading to the development of cardiovascular diseases. LÄS MER