Sökning: "neuron survival"

Visar resultat 11 - 15 av 78 avhandlingar innehållade orden neuron survival.

  1. 11. Survival and differentiation of central noradrenergic neurons

    Författare :Pontus Holm; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : About half of all central noradrenergic (NA) neurons reside in the locus coeruleus (LC). Projections from the LC reach target regions throughout the entire brain and regulate a variety of functions, such as mood, vigilance, arousal, sleep, attention and memory acquisition. LÄS MER

  3. 12. Role of transcription factors in sensory neuron specification

    Författare :Andreas Montelius; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The interface between our mind and the internal and external environments is the peripheral nervous system. A range of different sensory neuron subtypes detects cold, heat, pain, touch, and other stimuli. LÄS MER

  4. 13. Transcription factor control in neuronal maintenance and survival

    Författare :Banafsheh Kadkhodaei; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The Transcription factor (TF) Nurr1 is essential for the development of a group of dopamine neurons that are located in the ventral midbrain (also referred to as mesencephalon). A progressive pathology of these midbrain dopamine (mDA) neurons is evident in Parkinson s disease, the most frequent neurodegenerative movement disorder. LÄS MER

  5. 14. Inter- and intracellular resistance and vulnerability in motor neuron diseases

    Författare :Jik Nijssen; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA) are fatal diseases presenting with degeneration and loss of lower motor neurons in the brainstem and spinal cord. However, oculomotor and trochlear motor neurons that control eye movement, are resistant until late stages of disease. LÄS MER

  7. 15. Neuroprotection and neurogenesis after experimental stroke

    Författare :Andreas Arvidsson; Lund Neurologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; stereology; rat; Neurology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi; BrdU; immunohistochemistry; in situ hybridization; subventricular zone; striatum; dentate gyrus; neuronal replacement; neuronal survival; Focal cerebral ischemia; glial cell line-derived neurotrophic factor;

    Sammanfattning : In this thesis, two potential endogenous mechanisms for neuronal survival and repair have been investigated in a rat model of stroke, middle cerebral artery occlusion (MCAO): signaling of the GDNF family of neurotrophic factors, and neurogenesis from endogenous progenitor cells. As determined by in situ hybridization for GDNF family ligand and receptor genes, MCAO caused widespread upregulation of both components of the functional GDNF receptor, c-Ret and GFRalpha1, indicating that GDNF may be a survival signal in stroke. LÄS MER