Sökning: "neurogenesis developing brain"

Visar resultat 11 - 15 av 16 avhandlingar innehållade orden neurogenesis developing brain.

  1. 11. Genetic Sex Differences in Early Human Neuronal Development : An Investigation in Embryo Tissue and Embryonic Stem Cells

    Författare :Philipp Pottmeier; Elena Jazin; Armin Raznahan; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; sex chromosome; gametolog; x y homolog; male; female; sex differences; sex bias; embryonic stem cells; neurodevelopment; neuronal differentiation; neural stem cells; genetics; neurodevelopmental disorders; Biology with specialization in Evolutionary Organismal Biology; Biologi med inriktning mot evolutionär organismbiologi; Neuroscience; Neurovetenskap; Medicinsk genetik; Medical Genetics;

    Sammanfattning : Sex differences in the human body affect many different organs and tissues, some of them have an effect on the human brain and its development. In the developing nervous system, sex differences can bias the number or functionality of neurons, glial cells or synapses. As a result, neural networks might develop with a sex-specific bias. LÄS MER

  3. 12. On Nogo signaling regulation

    Författare :Alexandra Trifunovski; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Nogo; Nogo receptor; regulation; neurotrophin; Lingo-1; p75NTR; Troy; synaptic plasticity;

    Sammanfattning : As neuronal development enters its final stages, axon growth becomes restricted. This lack of regenerative capacity is partly due to the non-permissive environment of growth inhibitory proteins. Three such proteins, Nogo, OMgp and MAG bind to the same receptor, the Nogo receptor (NgR) and induce growth cone collapse and axon growth inhibition. LÄS MER

  4. 13. Studies of presenilin function in neurodegeneration and in human embryonic CNS during development

    Författare :Beata Kostyszyn; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Presenilin-1 (PS1) and -2 (PS2) gene mutations cause early onset familial Alzheimer's disease (FAD). Presenilins provide gamma-secretase activity for cleaving transmembrane proteins such as the amyloid precursor protein (APP), Notch receptors and ligands. LÄS MER

  5. 14. Identification of novel Wnt/PCP signaling regulators and their role in midbrain dopaminergic neuron development and Parkinson's disease

    Författare :Alena Salašová; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Wnt signaling controls a wide spectrum of complex cell responses during prenatal development, in the adulthood and during disease. In this doctoral study, we have identified and explored novel regulatory components of Wnt/Planar Cell Polarity (PCP) pathway and their function in various cellular processes during embryogenesis and central nervous system (CNS) development. LÄS MER

  7. 15. Finding the ligand : retinoid receptor activation in the CNS

    Författare :Alexander Mata de Urquiza; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Nuclear hormone receptors (NRs) comprise a large family of ligand activated transcription factors, found in vertebrates, arthropods and nematodes. Among the members of the NR family are the receptors for small, lipophilic ligands such as the steroid hormones, vitamins A and D, thyroid hormone oxysterols and bile acids. LÄS MER