Sökning: "natural antibodies"

Visar resultat 26 - 30 av 352 avhandlingar innehållade orden natural antibodies.

  1. 26. Engineering Antibody Specificity Using Combinatorial Antibody Libraries

    Författare :Jenny Boström; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; antibody Antigen Interactions; Dual Specific Antibodies; Herceptin; Human Epidermal Growth Factor Receptor 2; Thermodynamic Analysis; therapeutic Antibody Engineering; Synthetic Phagedisplayed Antibody Libraries; Vascular Endothelial Growth Factor; Bacterial Display; trastuzumab;

    Sammanfattning : The research presented in this thesis investigates antibody specificity, antibody-antigen and protein-protein interactions using combinatorial antibody libraries, phage-display and bacterial display technology. One goal was to develop a method to generate antibodies that bind two protein antigens with high affinity using a single-antigen binding site, and to investigate the molecular and thermodynamic requirements for antibody multispecificity. LÄS MER

  3. 27. Genetics of colostrum, milk and serum antibodies in dairy cattle: implications for health and production

    Författare :Juan Cordero; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Colostrum with sufficient IgG content is essential for the newborn calf, as it requires this passive immunity to survive during its rearing. Failure of passive transfer (FPT) occurs when a calf does not absorb enough antibodies (... LÄS MER

  4. 28. Detection of Bio-analytes with Streaming Current : From Fundamental Principles to Novel Applications

    Författare :Siddharth S. Sahu; Apurba Dev; Shi-Li Zhang; Michel Calame; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Streaming current; Electrokinetic biosensor; Size and Charge effects; membrane protein profiling of extracellular vesicles; sandwich immunoassay; charge-labelled antibodies; multiplexed detection; exosome heterogeneity;

    Sammanfattning : A biosensor based on streaming current is a new and relatively unexplored subject with significant potential. This thesis attempts to gain a deeper understanding of the governing principles, and then exploit them to further improve its performance as well as develop novel applications. LÄS MER

  5. 29. Immunological studies of human bladder cancer (TCC) : analysis of the immune response and the use of anti-TCC antibodies for tumor localization

    Författare :Yngve Hansson; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : .... LÄS MER

  7. 30. Antibodies for better or worse or Antibody variability in an egg-laying mammal and a novel strategy in the treatment of allergies

    Författare :Jeannette Johansson; Kjell-Olov Grönvik; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; Antibody; variability; platypus; allergy; vaccine; adjuvant; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi; Molecular Immunology; molekylär immunologi;

    Sammanfattning : Antibodies are a central part of the immune defense system, and a large variability in their specificity is needed in order to be able to react against all possible foreign substances we may encounter during our lives. In this thesis, results are presented from investigations into how an egg-laying mammal, the Australian duck-billed platypus (Ornithorhynchus anatinus) creates antibody variability. LÄS MER