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Visar resultat 1 - 5 av 37 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Mitochondrial function in sepsis - Temporal evolvement of respiratory capacity in human blood cells

    Författare :Fredrik Sjövall; Lund Institutionen för kliniska vetenskaper; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; human; sepsis; severe sepsis; septic shock; platelets; mitochondria; OXPHOS; high-resolution respirometry; mitochondrial disorders; multiple organ failure; biogenesis; leukocytes; cytokines; respirometry; oxygen consumption; blood cells; temporal;

    Sammanfattning : Sepsis is a devastating disease that is caused by the host’s response to an overwhelming infectious process. As sepsis progresses, organs distant from the site of infection become affected and sepsis-induced multiple organ failure ensues. LÄS MER

  3. 2. Oxygen delivery and mitochondrial dysfunction as assessed by microdialysis during interventions in experimental sepsis

    Författare :Magnus von Seth; Lipscey Miklós; Jan Sjölin; Mats Eriksson; Jukka Takala; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; sepsis; animal models; microdialysis; endotoxin; Escherichia coli; tigecycline; doxycycline; albumins; capillary leak syndrome; lactic acid; oxygen delivery; multiple organ failure; mitochondria; tumor necrosis factor alpha; interleukin-6; cyanides; ouabain; Anestesiologi och intensivvård; Anaesthesiology and Intensive Care;

    Sammanfattning : Early administration of broad-spectrum antibiotics is the first goal in sepsis treatment. Besides from bacteriostatic/bactericidal effects, some antibiotics may also modify the host´s response to infection. The novel antibiotic tigecycline may exert such properties; however, this property has not been evaluated in large-animal trials. LÄS MER

  4. 3. Organ dysfunction among patients with major burns

    Författare :Ingrid Steinvall; Folke Sjöberg; Jyrki Vuola; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : The number of patients who are admitted for in-hospital care in Sweden because of burns is about 12/100,000, and only a small proportion of these have larger burns. Among them, and particularly among those who die in hospital, a condition referred to as “organ dysfunction” is common and an important factor in morbidity and mortality. LÄS MER

  5. 4. The liver in sepsis : a study of liver circulation and some aspects of liver function in experimental peritonitis and in patients with multiple system organ failure

    Författare :Dag Arvidsson; Uppsala universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : .... LÄS MER

  7. 5. Epidemiological studies on comorbidity, heritability and co-aggregation in organ-specific autoimmune diseases

    Författare :Jakob Skov; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Autoimmunity is caused by loss of tolerance, whereby the immune system fails to distinguish self from non-self. The autoimmune panorama entails more than 100 diseases that collectively affect close to 5% of the total population, with a higher prevalence in women than in men. LÄS MER